Anorexia nervosa as a disorder of the subcortical-cortical interoceptive-self.

Autor: Lucherini Angeletti L; Department of Health Sciences, Psychiatry Unit, University of Florence, Largo G. Alessandro Brambilla 3, 50134, Florence, Italy. lorenzo.lucherinibargelliniangeletti@unifi.it., Innocenti M; Department of Health Sciences, Psychiatry Unit, University of Florence, Largo G. Alessandro Brambilla 3, 50134, Florence, Italy., Felciai F; Department of Health Sciences, Psychiatry Unit, University of Florence, Largo G. Alessandro Brambilla 3, 50134, Florence, Italy., Ruggeri E; Department of Health Sciences, Psychiatry Unit, University of Florence, Largo G. Alessandro Brambilla 3, 50134, Florence, Italy., Cassioli E; Department of Health Sciences, Psychiatry Unit, University of Florence, Largo G. Alessandro Brambilla 3, 50134, Florence, Italy., Rossi E; Department of Health Sciences, Psychiatry Unit, University of Florence, Largo G. Alessandro Brambilla 3, 50134, Florence, Italy., Rotella F; AOU Careggi Hospital, Psychiatry Unit, Florence, Italy., Castellini G; Department of Health Sciences, Psychiatry Unit, University of Florence, Largo G. Alessandro Brambilla 3, 50134, Florence, Italy., Stanghellini G; Department of Health Sciences, Psychology Unit, University of Florence, Florence, Italy., Ricca V; Department of Health Sciences, Psychiatry Unit, University of Florence, Largo G. Alessandro Brambilla 3, 50134, Florence, Italy., Northoff G; Mental Health Centre, Zhejiang University School of Medicine, Hangzhou, China.; Centre for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China.; The Royal's Institute of Mental Health Research & University of Ottawa, Ottawa, ON, Canada.; Centre for Neural Dynamics, Faculty of Medicine, Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.
Jazyk: angličtina
Zdroj: Eating and weight disorders : EWD [Eat Weight Disord] 2022 Dec; Vol. 27 (8), pp. 3063-3081. Date of Electronic Publication: 2022 Nov 10.
DOI: 10.1007/s40519-022-01510-7
Abstrakt: Purpose: Anorexia nervosa (AN) is characterized by a diminished capacity in perceiving the physiological correlates of interoceptive sensations, namely bodily self-consciousness. Given the neural division of self-processing into interoceptive-, exteroceptive- and mental-self, we hypothesize neural deficits in the interoceptive-processing regions in AN.
Methods: To prove this, we reviewed resting state (rs), task and rest-task studies in AN literature.
Results: Neuronal data demonstrate the following in AN: (i) decreased rs-functional connectivity (rsFC) of subcortical-cortical midline structures (SCMS); (ii) reduced rsFC between medial (default-mode network/DMN and salience network/SN) and lateral (executive-control network/ECN) cortical regions; (iii) decreased rsFC in mainly the regions of the interoceptive-self; (iv) altered activity with overall increased activity in response to sensory/body image stimuli, especially in the regions of the interoceptive-self; (v) lack of a clear task-related distinction between own's and others' body image.
Conclusion: These data may indicate that rs-hypoconnectivity between SCMS, as neural correlate of a reduced intero-exteroceptive integration resulting in self-objectification, might be linked to overall increased activity in interoceptive regions during sensory/body image stimuli in AN, engendering an "anxious bodily self."
Level of Evidence: I: Systematic review.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz: