The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours.

Autor: Van Hese L; Division of Mass Spectrometry Imaging, Maastricht MultiModal Molecular Imaging (M4I) Institute, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.; Department of Anaesthesiology, University Hospitals Leuven, 3000, Leuven, Belgium.; Department of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium., De Vleeschouwer S; Neurosurgery Department, University Hospitals Leuven, 3000, Leuven, Belgium.; Laboratory for Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, Leuven Brain Institute (LBI), 3000, Leuven, Belgium., Theys T; Neurosurgery Department, University Hospitals Leuven, 3000, Leuven, Belgium.; Laboratory for Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, Leuven Brain Institute (LBI), 3000, Leuven, Belgium., Rex S; Department of Anaesthesiology, University Hospitals Leuven, 3000, Leuven, Belgium.; Department of Cardiovascular Sciences, KU Leuven, 3000, Leuven, Belgium., Heeren RMA; Division of Mass Spectrometry Imaging, Maastricht MultiModal Molecular Imaging (M4I) Institute, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands., Cuypers E; Division of Mass Spectrometry Imaging, Maastricht MultiModal Molecular Imaging (M4I) Institute, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands. e.cuypers@maastrichtuniversity.nl.
Jazyk: angličtina
Zdroj: Discover. Oncology [Discov Oncol] 2022 Nov 10; Vol. 13 (1), pp. 123. Date of Electronic Publication: 2022 Nov 10.
DOI: 10.1007/s12672-022-00585-z
Abstrakt: Brain tumour identification and delineation in a timeframe of seconds would significantly guide and support surgical decisions. Here, treatment is often complicated by the infiltration of gliomas in the surrounding brain parenchyma. Accurate delineation of the invasive margins is essential to increase the extent of resection and to avoid postoperative neurological deficits. Currently, histopathological annotation of brain biopsies and genetic phenotyping still define the first line treatment, where results become only available after surgery. Furthermore, adjuvant techniques to improve intraoperative visualisation of the tumour tissue have been developed and validated. In this review, we focused on the sensitivity and specificity of conventional techniques to characterise the tumour type and margin, specifically fluorescent-guided surgery, neuronavigation and intraoperative imaging as well as on more experimental techniques such as mass spectrometry-based diagnostics, Raman spectrometry and hyperspectral imaging. Based on our findings, all investigated methods had their advantages and limitations, guiding researchers towards the combined use of intraoperative imaging techniques. This can lead to an improved outcome in terms of extent of tumour resection and progression free survival while preserving neurological outcome of the patients.
(© 2022. The Author(s).)
Databáze: MEDLINE
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