Pd(II)-catalyzed annulation of terminal alkynes with 2-pyridinyl-substituted p -quinone methides: direct access to indolizines.

Autor: Ahmad F; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab, 140306, India. rvijayan@iisermohali.ac.in., Ranga PK; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab, 140306, India. rvijayan@iisermohali.ac.in., Pankhade YA; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab, 140306, India. rvijayan@iisermohali.ac.in., Fatma S; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab, 140306, India. rvijayan@iisermohali.ac.in., Gouda A; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab, 140306, India. rvijayan@iisermohali.ac.in., Anand RV; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab, 140306, India. rvijayan@iisermohali.ac.in.
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Nov 29; Vol. 58 (95), pp. 13238-13241. Date of Electronic Publication: 2022 Nov 29.
DOI: 10.1039/d2cc04395e
Abstrakt: A Pd-catalyzed direct method has been developed to access 1,3-disubstituted indolizines. This reaction proceeds through a regiospecific annulation of terminal alkynes with 2-pyridinyl-substituted p -quinone methides and, in most of the cases, the desired 1,3-disubstituted indolizines were obtained in moderate to good isolated yields. The control experiments suggested that the reaction does proceed through a substrate-controlled regiospecific formal [3 + 2]-annulation pathway.
Databáze: MEDLINE
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