Toxicological Assessment of Pure Lolitrem B and Ryegrass Seed Infected with the AR37 Endophyte Using Mice.

Autor: Finch SC; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand., Hawkes AD; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand., Fitzgerald JM; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand., Broadhurst RB; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand., Staincliffe MR; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand., Munday JS; School of Veterinary Science, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand.
Jazyk: angličtina
Zdroj: Journal of fungi (Basel, Switzerland) [J Fungi (Basel)] 2022 Oct 28; Vol. 8 (11). Date of Electronic Publication: 2022 Oct 28.
DOI: 10.3390/jof8111139
Abstrakt: Fungal endophytes in perennial ryegrass are essential to New Zealand's pastoral system due to anti-insect effects. However, endophytes also produce compounds which can be detrimental to animals. Furthermore, as these toxins have been detected in the milk and fat of animals grazing common-toxic (containing lolitrem B) or AR37 endophyte-infected herbage they could enter the human food chain. To assess the risk to human health mice were fed for 90 days with three dose rates of lolitrem B and of AR37. Parameters indicative of animal health were measured as well as chemical, hematological and histological analysis of samples collected on day 90. Since endophyte toxin residues have been detected in milk, they could be transferred from mother to offspring via breast milk. To evaluate possible effects on reproduction two complete generations of mice were fed lolitrem B or AR37. At the dose rates given no adverse effects were observed in either study. The 100-fold safety factor to allow the use of animal data in human health assessments was applied and by considering the concentrations of lolitrem B or AR37 metabolites which could be ingested by a consumer it is highly unlikely that they pose any risk to human health.
Databáze: MEDLINE
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