| Autor: |
Pakarinen S; Degree Program of Oral Hygiene, Metropolia University of Applied Sciences, 00920 Helsinki, Finland., Saarela RKT; Department of Oral Health, Health and Social Services, 00530 Helsinki, Finland., Välimaa H; Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland., Heikkinen AM; Faculty of Medicine and Health Technology, University of Tampere, 33520 Tampere, Finland., Kankuri E; Department of Pharmacology, Helsinki University, 00100 Helsinki, Finland., Noponen M; Department of Oral Health, Health and Social Services, 00530 Helsinki, Finland.; Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland., Alapulli H; Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland.; Department of Pediatric Dentistry, New Children's Hospital, University of Helsinki, 00290 Helsinki, Finland., Tervahartiala T; Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland., Räisänen IT; Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland., Sorsa T; Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland.; Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, 14152 Huddinge, Sweden., Pätilä T; Department of Congenital Heart Surgery and Organ Transplantation, New Children's Hospital, University of Helsinki, 00290 Helsinki, Finland. |
| Abstrakt: |
A single-site, randomized clinical trial was designed to determine the efficacy of regular home use of Lumoral ® dual-light antibacterial aPDT in periodontitis patients. For the study, 200 patients were randomized to receive non-surgical periodontal treatment (NSPT), including standardized hygiene instructions and electric toothbrush, scaling and root planing, or NSPT with adjunctive Lumoral ® treatment. A complete clinical intraoral examination was conducted in the beginning, at three months, and at six months. This report presents the three-month results of the first 59 consecutive randomized subjects. At three months, bleeding on probing (BOP) was lower in the NSPT + Lumoral ® -group than in the NSPT group ( p = 0.045), and more patients in the NSPT + Lumoral ® -group had their BOP below 10% (54% vs. 22%, respectively, p = 0.008). In addition, patients in the NSPT + Lumoral ® -group improved their oral hygiene by visible-plaque-index ( p = 0.0003), while the NSPT group showed no statistical improvement compared to the baseline. Both groups significantly reduced the number of deep periodontal pockets, but more patients with a reduction in their deep pocket number were found in the NSPT + Lumoral ® group (92% vs. 63%, p = 0.02). Patients whose number of deep pockets was reduced by 50% or more were also more frequent in the NSPT + Lumoral ® -group (71% vs. 33%, p = 0.01). Patients with initially less than ten deep pockets had fewer deep pockets at the three-month follow-up in the Lumoral ® group ( p = 0.01). In conclusion, adjunctive use of Lumoral ® in NSPT results in improved treatment outcomes at three months post-therapy. |
