Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes.

Autor:	Posso-Osorio I; Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali 760031, Colombia.; Fundación Valle del Lili, Unidad de Reumatología, Cali, Colombia., Rios-Serna LJ; Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali 760031, Colombia., Rosero AM; Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali 760031, Colombia.; Universidad del Valle, Escuela de Bacteriología y Laboratorio Clínico, Facultad de Salud, Cali, Colombia., Cárdenas D; Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali 760031, Colombia., Tobón GJ; Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, USA., Cañas CA; Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali 760031, Colombia.; Fundación Valle del Lili, Unidad de Reumatología, Cali, Colombia.
Jazyk:	angličtina
Zdroj:	Journal of translational autoimmunity [J Transl Autoimmun] 2022 Oct 29; Vol. 5, pp. 100170. Date of Electronic Publication: 2022 Oct 29 (Print Publication: 2022).
DOI:	10.1016/j.jtauto.2022.100170
Abstrakt:	We report a case of 65-year-old male patient with primary hyperparathyroidism (PHPT) who was admitted to the hospital for autoimmune manifestations (including autoimmune hepatitis and autoantibody development) and exhibited subsequent clinical and paraclinical improvement after parathyroidectomy. By flow cytometry, the expression of PTH receptor 1 (PTHR1) on B lymphocytes of peripheral blood was documented to be higher than that in healthy controls. After parathyroidectomy, autoimmune manifestations improved, while PTH1R expression on B-lymphocytes increased. The possible role of the dynamics of B-lymphocyte PTHR1 in the development of this autoimmune phenomenon is discussed. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Gabriel J. Tobon reports financial support was provided by Colombia Ministry of Science Technology and Innovation. (© 2022 Published by Elsevier B.V.)
Databáze:	MEDLINE
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