A Fenestrated Balloon Expandable Stent System for the Treatment of Aortoiliac Occlusive Disease.
| Autor: | Cashin JL; Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO 63110., Wirtz AJ; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130., Genin GM; NSF Science and Technology Center for Engineering Mechanobiology, Washington University in St. Louis, St. Louis, MO 63130; Departments of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130; Department of Neurological Surgery, Washington University in St. Louis, St. Louis, MO 63130., Zayed M; Cardiovascular Research Innovation in Surgery & Engineering Center, and the Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO 63110. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of engineering and science in medical diagnostics and therapy [J Eng Sci Med Diagn Ther] 2023 Feb 01; Vol. 6 (1), pp. 011004. Date of Electronic Publication: 2022 Nov 01. |
| DOI: | 10.1115/1.4055877 |
| Abstrakt: | In aortoiliac occlusive disease, atherosclerotic plaques can occlude the distal aortic bifurcation and proximal bilateral iliac artery and thus cause ischemia in the lower extremity. This is typically treated by restoring patency with balloon expandable stents. Stents are typically deployed in a "kissing stent" configuration into the bilateral iliac arteries and into the distal aortic bifurcation lumen to restore antegrade arterial flow. However, these stents typically become re-occluded by plaques. To understand the reasons for this and look for solutions, we simulated flow dynamics in the aortic bifurcation in the presence and absence of stents using computational fluid dynamics. Results demonstrated that the kissing stent configuration was associated with high levels of vorticity and flow constriction. These prothrombotic variables were alleviated in an alternative, aortoiliac fenestrated (AIFEN), tapered, and balloon-expandable stent design. Our findings suggest that stent design can be tailored to improve flow fields for aortoiliac stenting. (Copyright © 2023 by ASME.) |
| Databáze: | MEDLINE |
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