| Autor: |
Kotas ME; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, California, USA.; Department of Medicine, University of California, San Francisco, California, USA., O'Leary CE; Department of Medicine, University of California, San Francisco, California, USA.; Current affiliation: Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Locksley RM; Department of Medicine, University of California, San Francisco, California, USA.; Department of Microbiology and Immunology, University of California, San Francisco, California, USA; email: richard.locksley@ucsf.edu.; Howard Hughes Medical Institute, University of California, San Francisco, California, USA. |
| Abstrakt: |
Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and luminal exposures but converge on a shared transcriptional program, including expression of taste transduction signaling pathways. Here, we summarize seminal and recent findings on tuft cells, focusing on major categories of function-instigation of type 2 cytokine responses, orchestration of antimicrobial responses, and emerging roles in tissue repair-and describe tuft cell-derived molecules used to affect these functional programs. We review what is known about the development of tuft cells from epithelial progenitors under homeostatic conditions and during disease. Finally, we discuss evidence that immature, or nascent, tuft cells with potential for diverse functions are driven toward dominant effector programs by tissue- or perturbation-specific contextual cues, which may result in heterogeneous mature tuft cell phenotypes both within and between tissues. |
