Association of Interleukin-17F Polymorphism and Mortality Predictors with the Risk of COVID-19.

Autor: El-Desoky MM; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Tharwat S; Rheumatology & Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Mostafa N; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Hewidy AA; Chest Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Elmorsey RA; Chest Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Abdelhafez MS; Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., El-Ashry AH; Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Elhendawi MM; Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Fathy AA; Public Health and Community Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Hisham FA; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Jazyk: angličtina
Zdroj: International journal of clinical practice [Int J Clin Pract] 2022 Oct 27; Vol. 2022, pp. 4761631. Date of Electronic Publication: 2022 Oct 27 (Print Publication: 2022).
DOI: 10.1155/2022/4761631
Abstrakt: Background: Th-17 cells, a proinflammatory subset of CD4 T lymphocytes, have been suggested as a possible cause of coronavirus disease-19 (COVID-19)-related immunological injuries. The aim of this study was to investigate the relationship between IL-17F (rs763780) polymorphism and the susceptibility to and outcomes of COVID-19 infection and to determine the clinical and laboratory predictors of COVID-19 death.
Methods: This case-control study included 132 COVID-19 patients and 135 healthy age- and sex-matched controls. The participants were tested for IL-17F rs763780 polymorphism via TaqMan-based genotyping and for the expression of IL-17 by enzyme-linked immunosorbent assay. This study also investigated the predictors for COVID-19 mortality.
Results: A non-statistically significant association was observed between IL-17F alleles and genotypes with COVID-19 ( P =0.309, P =0.138, respectively). Moreover, no significant difference in the IL-17F genotypes was observed between non-survivors and survivors ( P =0.482). In the multivariate analysis, the participants with the following characteristics had 17.7-, 11.2-, 8-, and 17.9-fold higher odds of exhibiting in-hospital mortality, respectively: (1) hypertension, (2) age of >57 years, (3) WBC count of >12.6 × 10 3 /mm 3 , and (4) D-dimer of >0.9 ng/ml. The ROC curve analysis showed that IL-17 at a cutoff point of >46 pg/ml was a perfect discriminator of COVID-19 patients from control subjects (AUC = 1.0).
Conclusion: The findings indicate that the IL-17F H161R variant does not influence the risk of COVID-19. However, the IL-17 level is a perfect discriminator of COVID-19 infection. Hypertension, age of >57 years, white blood cell count of >12.6 × 10 3 /mm 3 , and D-dimer of >0.9 ng/ml are the independent predictors for death among COVID-19 patients.
Competing Interests: All authors declare that they have no conflicts of interest.
(Copyright © 2022 Manal M. El-Desoky et al.)
Databáze: MEDLINE
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