Effects of systemic vascular photobiomodulation using LED or laser on sensory-motor recovery following a peripheral nerve injury in Wistar rats.

Autor: Araujo T; Universidade Nove de Julho (UNINOVE), 235/249 Vergueiro Street, São Paulo, SP, 01525000, Brazil., Andreo L; Universidade Nove de Julho (UNINOVE), 235/249 Vergueiro Street, São Paulo, SP, 01525000, Brazil., Tobelem DDC; Universidade Nove de Julho (UNINOVE), 235/249 Vergueiro Street, São Paulo, SP, 01525000, Brazil., Silva T; Universidade Nove de Julho (UNINOVE), 235/249 Vergueiro Street, São Paulo, SP, 01525000, Brazil., Malavazzi TCDS; Universidade Nove de Julho (UNINOVE), 235/249 Vergueiro Street, São Paulo, SP, 01525000, Brazil., Martinelli A; Universidade Nove de Julho (UNINOVE), 235/249 Vergueiro Street, São Paulo, SP, 01525000, Brazil., Lemes B; Laboratory of Physiology and Cardiac Pathophysiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, 04040003, Brazil., Fernandes KPS; Universidade Nove de Julho (UNINOVE), 235/249 Vergueiro Street, São Paulo, SP, 01525000, Brazil., Bussadori SK; Universidade Nove de Julho (UNINOVE), 235/249 Vergueiro Street, São Paulo, SP, 01525000, Brazil., Mesquita-Ferrari RA; Universidade Nove de Julho (UNINOVE), 235/249 Vergueiro Street, São Paulo, SP, 01525000, Brazil. raquel.mesquita@gmail.com.
Jazyk: angličtina
Zdroj: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology [Photochem Photobiol Sci] 2023 Mar; Vol. 22 (3), pp. 567-577. Date of Electronic Publication: 2022 Nov 09.
DOI: 10.1007/s43630-022-00335-8
Abstrakt: Peripheral nerve injury (PNI) is associated with considerable functional impairment. Photobiomodulation (PBM) has demonstrated positive effects regarding neuromuscular repair after PNI when applied locally to the nerve or injured muscle. However, the effects of systemic PBM with transcutaneous application over an important artery, which is also denominated vascular PBM (VPBM), remain unclear. The aim of the study was to compare the effects of VPBM with low-level laser (LLL) and light-emitting diode (LED) on gait, sensitivity and muscle morphology following a PNI. PNI was induced on Wistar rats using the sciatic nerve crushing technique. VPBM was performed over the rat's artery tail region with LED (850 nm, 40 mW, 3.2 J) and LLL (780 nm, 40 mW, 3.2 J). Gait functionality, mechanical (nociceptive) sensitivity, and morphology of the tibialis anterior muscle were evaluated at 7, 14, and 21 days after injury. An improvement in functional gait was shown in the VPBM-LLL group in all periods. Motor sensitivity was found after 14 days in the VPBM-LLL group. The left/right (L/R) muscle mass ratio revealed a reduction in muscle atrophy in the VPBM-LLL group at 7 days. Muscle fiber diameter increased in the VPBM-LED group at 14 days and increases in the cross-section area were found in the VPBM-LED and VPBM-LLL groups at 7 days. VPBM with both light sources (LED and LLL) positively modulated functioning and neuromuscular recovery following sciatic nerve injury in rats, with more pronounced results when using LLL.
(© 2022. The Author(s), under exclusive licence to European Photochemistry Association, European Society for Photobiology.)
Databáze: MEDLINE
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