Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle.

Autor:	El Dika M; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Fritz AJ; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Toor RH; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Rodriguez PD; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, USA., Foley SJ; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Ullah R; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Nie D; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Banerjee B; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Lohese D; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Tracy KM; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Glass KC; Department of Pharmacology, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Frietze S; College of Nursing and Health Sciences, University of Vermont, Burlington, VT, USA., Ghule PN; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Heath JL; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.; Department of Pediatrics, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Imbalzano AN; Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA, USA., van Wijnen A; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Gordon J; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Lian JB; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Stein JL; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA., Stein GS; Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.
Jazyk:	angličtina
Zdroj:	Results and problems in cell differentiation [Results Probl Cell Differ] 2022; Vol. 70, pp. 375-396.
DOI:	10.1007/978-3-031-06573-6_13
Abstrakt:	The cell cycle is governed by stringent epigenetic mechanisms that, in response to intrinsic and extrinsic regulatory cues, support fidelity of DNA replication and cell division. We will focus on (1) the complex and interdependent processes that are obligatory for control of proliferation and compromised in cancer, (2) epigenetic and topological domains that are associated with distinct phases of the cell cycle that may be altered in cancer initiation and progression, and (3) the requirement for mitotic bookmarking to maintain intranuclear localization of transcriptional regulatory machinery to reinforce cell identity throughout the cell cycle to prevent malignant transformation. (© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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