Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility.

Autor: Park S; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA., Casanova MI; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA., Bannasch DL; Department of Population Health and Reproduction, University of California-Davis, Davis, CA, 95616, USA., Daley NL; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA., Kim S; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA., Kuchtey J; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Gomes FE; Department of Clinical Sciences, College of Veterinary Medicine, Cornell University Ithaca, New York, 14853, USA.; Small Animal Specialist Hospital, North Ryde, NSW, 2113, Australia., Leonard BC; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA., Good KL; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA., Martins BDC; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA., Murphy CJ; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.; Department of Ophthalmology & Vision Science, School of Medicine, University of California-Davis, Davis, CA, 95817, USA., Thomasy SM; Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA. smthomasy@ucdavis.edu.; Department of Ophthalmology & Vision Science, School of Medicine, University of California-Davis, Davis, CA, 95817, USA. smthomasy@ucdavis.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Nov 08; Vol. 12 (1), pp. 18980. Date of Electronic Publication: 2022 Nov 08.
DOI: 10.1038/s41598-022-23238-1
Abstrakt: Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG in most of canine breeds is epidemiologically similar to humans with older and female patients overrepresented with the condition. The American Cocker Spaniel (ACS) is among the most common breeds observed with PACG development in dogs. This study initially sought to identify genetic risk factors to explain the high prevalence of PACG in ACSs by using a case-control breed-matched genome-wide association study. However, the GWAS failed to identify candidate loci associated with PACG in this breed. This study then assessed intrinsic ocular morphologic traits that may relate to PACG susceptibility in this breed. Normal ACSs without glaucoma have a crowded anterior ocular segment and narrow iridocorneal angle and ciliary cleft, which is consistent with anatomical risk factors identified in humans. The ACSs showed unique features consisting of posterior bowing of iris and longer iridolenticular contact, which mirrors reverse pupillary block and pigment dispersion syndrome in humans. The ACS could hold potential to serve as an animal model of naturally occurring PACG in humans.
(© 2022. The Author(s).)
Databáze: MEDLINE
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