The effect of plasma transfusion in an experimental two-hit animal model of transfusion-associated circulatory overload with heart failure.
| Autor: | Bulle EB; Department of Intensive Care, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Klanderman RB; Department of Intensive Care, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Department of Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., de Wissel MB; Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Roelofs JJTH; Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Microcirculation, University of Amsterdam, Amsterdam, the Netherlands., Veelo DP; Department of Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van den Brom CE; Department of Intensive Care, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Department of Anesthesiology, Amsterdam UMC, VU University, Amsterdam, the Netherlands., Kapur R; Sanquin Research, Department of Experimental Immunohematology, Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Vlaar APJ; Department of Intensive Care, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. |
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| Jazyk: | angličtina |
| Zdroj: | Blood transfusion = Trasfusione del sangue [Blood Transfus] 2023 May; Vol. 21 (3), pp. 218-226. Date of Electronic Publication: 2022 Nov 04. |
| DOI: | 10.2450/2022.0141-22 |
| Abstrakt: | Background: Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-related morbidity and mortality. TACO follows a two-hit pathophysiology, where comorbidities like cardiac or renal failure act as the first hit followed by blood transfusion as a second hit. Observational studies suggest that plasma transfusion is more likely to cause TACO than other blood products. We conducted a randomized animal study to gather evidence that plasma transfusion can induce TACO. Material and Methods: As a first hit a large myocardial infarction was created in male Wistar rats. Then animals were randomized to receive 4 units of solvent/ detergent-treated pooled plasma (SDP), fresh frozen plasma (FFP), a colloid control (albumin 5%) or a crystalloid fluid control (Ringer's lactate) (n=10 per group). The primary outcome was the difference between pre- and post-transfusion left-ventricular end diastolic pressure (ΔLVEDP). Secondary outcomes were markers for acute lung injury; lung wet/dry weight ratio, PaO Results: Pre-transfusion characteristics were similar between groups. ΔLVEDP increased significantly after transfusion with SDP (7.7 mmHg; 4.5-10.5) and albumin (13.0 mmHg; 6.5-15.2), but not after FFP (7.9 mmHg, 1.1; 11.3) compared to infusion with Ringer's lactate (0.6 mmHg; 0.4-2.2), p=0.007, p=0.0005 and p=0.14 respectively. There were no significant differences in ΔLVEDP between groups receiving SDP, FFP or albumin. There was no increase in acute lung injury in any group compared to other groups. Discussion: Circulatory overload, measured as ΔLVEDP, was induced after transfusion of SDP or albumin, but not after infusion of Ringer's lactate. These results show that the effect of plasma transfusion on ΔLVEDP differs from fluid overload induced by crystalloid infusion. Colloid osmotic pressure may be an important component in the development of TACO and should be a target for future research. |
| Databáze: | MEDLINE |
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