Molecular Dynamics Methods for Antibody Design.
| Autor: | Childers MC; Department of Bioengineering, University of Washington, Seattle, WA, USA., Daggett V; Department of Bioengineering, University of Washington, Seattle, WA, USA. daggett@uw.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2552, pp. 109-124. |
| DOI: | 10.1007/978-1-0716-2609-2_5 |
| Abstrakt: | Complex and coordinated dynamics are closely connected with protein functions, including the binding of antibodies to antigens. Knowledge of such dynamics could improve the design of antibodies. Molecular dynamics (MD) simulations provide a "computational microscope" that can resolve atomic motions and inform antibody design efforts. (© 2023. Springer Science+Business Media, LLC, part of Springer Nature.) |
| Databáze: | MEDLINE |
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