Amlodipine and Diltiazem Significantly Repress Human Rotavirus Infection In Vitro .
| Autor: | Khales P; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Keyvani H; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Ataei-Pirkooh A; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Saghafi MM; Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Iran University of Medical Sciences, Tehran, Iran.; Department of Pharmaceutical care, Teaching Hospital Firooz-Abadi, Iran University of Medical Sciences, Tehran, Iran., Bokharaei-Salim F; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Ghorbani S; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Monavari SH; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Kiani SJ; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Esghaei M; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Farahmand M; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran., Sayyahfar S; Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran., Khanaliha K; Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran., Habib Z; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Tavakoli A; Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Recent advances in anti-infective drug discovery [Recent Adv Antiinfect Drug Discov] 2023; Vol. 18 (3), pp. 205-214. |
| DOI: | 10.2174/2772434418666221107105624 |
| Abstrakt: | Background: Considering the role of calcium in the replication and morphogenesis of rotaviruses, it is hypothesized that decreased cytosolic calcium levels by using calcium channel blockers can subsequently interfere with rotavirus replication. Objective: The present study investigated the effects of two calcium ion channel blockers, amlodipine and diltiazem, against human rotavirus infection. Methods: Cytotoxic effects of the drugs on MA-104 cells were evaluated using the neutral red assay. The effects of amlodipine and diltiazem at non-toxic concentrations on human rotavirus were examined using cytopathic effect inhibition, TCID Results: The highest inhibitory effect was obtained at concentrations of 0.5 μg/ml of amlodipine and 3 μg/ml of diltiazem, leading to 4.6 and 5.5 logarithmic reductions in infectious rotavirus titer and four- and a five-fold increase in the C Conclusion: Our study suggests that in addition to cardiovascular diseases, calcium channel blockers at their optimal doses may also be used to treat gastroenteritis caused by rotavirus infection. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Databáze: | MEDLINE |
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