A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila.

Autor: Malita A; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Kubrak O; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Koyama T; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Ahrentløv N; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Texada MJ; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Nagy S; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Halberg KV; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Rewitz K; Department of Biology, University of Copenhagen, Copenhagen, Denmark. Kim.Rewitz@bio.ku.dk.
Jazyk: angličtina
Zdroj: Nature metabolism [Nat Metab] 2022 Nov; Vol. 4 (11), pp. 1532-1550. Date of Electronic Publication: 2022 Nov 07.
DOI: 10.1038/s42255-022-00672-z
Abstrakt: Animals must adapt their dietary choices to meet their nutritional needs. How these needs are detected and translated into nutrient-specific appetites that drive food-choice behaviours is poorly understood. Here we show that enteroendocrine cells of the adult female Drosophila midgut sense nutrients and in response release neuropeptide F (NPF), which is an ortholog of mammalian neuropeptide Y-family gut-brain hormones. Gut-derived NPF acts on glucagon-like adipokinetic hormone (AKH) signalling to induce sugar satiety and increase consumption of protein-rich food, and on adipose tissue to promote storage of ingested nutrients. Suppression of NPF-mediated gut signalling leads to overconsumption of dietary sugar while simultaneously decreasing intake of protein-rich yeast. Furthermore, gut-derived NPF has a female-specific function in promoting consumption of protein-containing food in mated females. Together, our findings suggest that gut NPF-to-AKH signalling modulates specific appetites and regulates food choice to ensure homeostatic consumption of nutrients, providing insight into the hormonal mechanisms that underlie nutrient-specific hungers.
(© 2022. The Author(s).)
Databáze: MEDLINE
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