Profile and Potential Significance of Dendritic Cells in Head and Neck Squamous Cell Carcinoma.

Autor:	Dumitru CS; Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 'Victor Babes' University of Medicine and Pharmacy, Timisoara, Romania., Ceausu AR; Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 'Victor Babes' University of Medicine and Pharmacy, Timisoara, Romania., Gaje NP; Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 'Victor Babes' University of Medicine and Pharmacy, Timisoara, Romania., Raica M; Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 'Victor Babes' University of Medicine and Pharmacy, Timisoara, Romania.
Jazyk:	angličtina
Zdroj:	Cancer diagnosis & prognosis [Cancer Diagn Progn] 2022 Nov 03; Vol. 2 (6), pp. 758-763. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).
DOI:	10.21873/cdp.10171
Abstrakt:	Background/aim: The aim of the study was the analysis of immunohistochemical expression of S100 protein and CD1a by dendritic cells (DCs) from head and neck squamous cell carcinoma (HNSCC), correlation with the histological grade, as well as analysis of the potential significance of antigen-presenting cells according to tumor location. Patients and Methods: Samples were collected from 50 patients with HNSCC, conventionally stained with hematoxylin and eosin for pathological diagnosis and grade, followed by immunohistochemical evaluation with S100 protein and CD1a expression. Results: The correlation of S100 expression in DCs with histological grading was significant (p=0.049). We also observed a correlation between CD1a expression and histological grading (p=0.016). DCs density was predominantly intratumoral for both CD1a (63% of cases) and S100 protein expression (25% of cases). Conclusion: Our results demonstrated the association of DCs with histological grade. Their intratumoral infiltration suggests their potential antitumor role. Competing Interests: The Authors declare no conflicts of interest. (Copyright 2022, International Institute of Anticancer Research.)
Databáze:	MEDLINE
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