Mucormycosis: A comparative update between conventional and molecular diagnosis strategies.

Autor:	Mudgal S; Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India., Rao S; Department of Pathology and Lab Medicine, Division of Molecular Biology, Metabolomics and Proteomics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India., Pai MO; Division of Microbiology (DRDO-RJSR), All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Jazyk:	angličtina
Zdroj:	Current medical mycology [Curr Med Mycol] 2022 Mar; Vol. 8 (1), pp. 44-53.
DOI:	10.18502/cmm.8.1.9214
Abstrakt:	Mucormycosis is an opportunistic, aggressive, and angioinvasive fungal infection associated with a high mortality rate as it disseminates and infects the whole body if not treated early. Most conventional diagnostic methods require time and may also generate false-negative reports due to the several lacunae associated. On the other hand, molecular methods are rapid, reliable, and can be applied to different biological samples, such as fresh tissue, formalin-fixed paraffin-embedded blocks, serum, and urine. Mucorales are angio-invasive, and many studies have found the circulating fungal DNA (a non-invasive form of DNA) in the blood and urine of the patient. In addition, with the increase in the usage of steroid drugs in this COVID scenario, the rate of mucormycosis infection has taken a sudden rise. In light of this situation, there is an imperative need to diagnose these infections at the earliest. Competing Interests: The authors declare that they have no conflict of interest regarding the publication of the present study. (Copyright: © 2021, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center.)
Databáze:	MEDLINE
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