Antimicrobial activity of polyhexamethylene biguanide nanoparticles against mastitis-causing Staphylococcus aureus .
Autor: | Leite RF; Department of Nutrition and Animal Production, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, Brazil, 13635-900., Gonçalves JL; Department of Nutrition and Animal Production, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, Brazil, 13635-900., Buanz A; Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, WC1N 1AX, United Kingdom., Febraro C; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, NW1 0TU, United Kingdom., Craig D; Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, WC1N 1AX, United Kingdom., Van Winden S; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, NW1 0TU, United Kingdom., Good L; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, NW1 0TU, United Kingdom., Santos MV; Department of Nutrition and Animal Production, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, Brazil, 13635-900. |
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Jazyk: | angličtina |
Zdroj: | JDS communications [JDS Commun] 2021 Jul 01; Vol. 2 (5), pp. 262-265. Date of Electronic Publication: 2021 Jul 01 (Print Publication: 2021). |
DOI: | 10.3168/jdsc.2021-0114 |
Abstrakt: | Postmilking teat disinfection is one of the main measures used to prevent mastitis caused by contagious pathogens, such as Staphylococcus aureus. The present study evaluated the antimicrobial activity of polyhexamethylene biguanide (PHMB) and PHMB nanoparticles (NP) against mastitis-causing Staph. aureus using a microdilution assay methodology. A total of 20 mastitis-causing Staph. aureus isolates were used to determine the minimum inhibitory concentrations (MIC) of PHMB and PHMB NP compared with 3 disinfectants commonly used for teat disinfection (chlorhexidine digluconate, povidone-iodine, and sodium dichloroisocyanurate). The MIC (© 2021.) |
Databáze: | MEDLINE |
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