Jamestown Canyon and snowshoe hare virus seroprevalence in New Brunswick.

Autor:	Mincer J; Dalhousie Medicine New Brunswick, Dalhousie University, Saint John, New Brunswick, Canada., Materniak S; Horizon Health Network, Saint John, New Brunswick, Canada., Dimitrova K; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Wood H; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Iranpour M; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Dibernardo A; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Loomer C; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Drebot MA; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Lindsay LR; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Webster D; Dalhousie Medicine New Brunswick, Dalhousie University, Saint John, New Brunswick, Canada.; Horizon Health Network, Saint John, New Brunswick, Canada.; Division of Infectious Diseases, Saint John Regional Hospital, Saint John, New Brunswick, Canada.
Jazyk:	angličtina
Zdroj:	Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada [J Assoc Med Microbiol Infect Dis Can] 2021 Sep 30; Vol. 6 (3), pp. 213-220. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).
DOI:	10.3138/jammi-2021-0009
Abstrakt:	Background: Jamestown Canyon virus (JCV) and snowshoe hare virus (SSHV) are wide-ranging mosquito-borne arboviruses in the California serogroup viruses (CSGV) that are known to circulate in New Brunswick. Despite potential for debilitating central nervous system manifestations, the prevalence of human exposure to these viruses in New Brunswick is unknown. The goal of this study was to quantify rates of human exposure in New Brunswick to these neglected arboviruses. Methods: A retrospective, anonymized provincial serosurvey was performed using a stratified random sample of residual sera submitted between May 2015 and August 2016. To determine the seroprevalence of JCV and SSHV, competitive enzyme-linked immunosorbent assay-positive samples were confirmed positive using plaque-reduction neutralization testing (PRNT). Results: A total of 452 serum samples were screened. The seroprevalence of antibodies against CSGV was estimated to be 31.6% (95% CI 27.4% to 36.1%) with 143 positive samples. PRNT results indicated that most single virus exposures were due to JCV (38 of 143; 26.6%) rather than SSHV (3 of 143; 2.1%). The species of CSGV, to which the remaining 102 seropositive people were exposed, could not be precisely determined. Conclusions: The prevalence of human exposure to CSGV is high but comparable to rates observed in other Atlantic Canadian jurisdictions. Studies such as this provide important baseline epidemiological data regarding the risk of exposure to these neglected arboviruses. SSHV and JCV should be considered in the differential diagnosis for undiagnosed febrile and neuroinvasive illness during mosquito season, particularly when testing for common aetiologies is negative or inconclusive. Competing Interests: The authors have nothing to disclose. (Copyright © 2021, Association of Medical Microbiology and Infectious Disease Canada (AMMI Canada).)
Databáze:	MEDLINE
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