Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel.

Autor: Bokhari RS; Agile Decision Sciences, NRESS, Arlington, VA 22202, United States of America. Electronic address: rbokhari@nasaprs.com., Beheshti A; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, 94035, United States of America; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, United States of America., Blutt SE; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States of America; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States of America., Bowles DE; Division of Surgical Sciences, Department of Surgery, Duke University, Durham NC, United States of America., Brenner D; Columbia University, New York, NY, 10027, United States of America., Britton R; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States of America., Bronk L; The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, United States of America., Cao X; Stanford University School of Medicine, Stanford, CA 94305, United States of America., Chatterjee A; Sachi Bioworks, Louisville, CO 80027, United States of America; University of Colorado Boulder, Boulder, CO 80303, United States of America., Clay DE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, United States of America., Courtney C; Sachi Bioworks, Louisville, CO 80027, United States of America., Fox DT; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, United States of America., Gaber MW; Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States of America., Gerecht S; Chemical and Biomolecular Engineering and Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218 United States of America; Biomedical Engineering, Duke University, Durham, NC 27708, United States of America., Grabham P; Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10027 United States of America., Grosshans D; The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, United States of America., Guan F; The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, United States of America., Jezuit EA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, United States of America., Kirsch DG; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, United States of America., Liu Z; Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States of America; Jan and Dan Duncan Neurological Research Institute, 1250 Moursund St. Houston, TX 77030, United States of America., Maletic-Savatic M; Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States of America; Jan and Dan Duncan Neurological Research Institute, 1250 Moursund St. Houston, TX 77030, United States of America., Miller KM; Department of Molecular Biosciences, The University of Texas, Austin, TX 78712, United States of America., Montague RA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, United States of America., Nagpal P; Sachi Bioworks, Louisville, CO 80027, United States of America., Osenberg S; Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States of America; Jan and Dan Duncan Neurological Research Institute, 1250 Moursund St. Houston, TX 77030, United States of America., Parkitny L; Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States of America; Jan and Dan Duncan Neurological Research Institute, 1250 Moursund St. Houston, TX 77030, United States of America., Pierce NA; Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States of America; Division of Engineering & Applied Science, California Institute of Technology, Pasadena, CA 91125, United States of America; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom., Porada C; Wake Forest Institute for Regenerative Medicine, Fetal Research and Therapy Program Wake Forest School of Medicine, Winston-Salem, NC 27157, United States of America., Rosenberg SM; Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77303, United States of America; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77303, United States of America; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77303, United States of America; Department of Molecular Virology and Microbiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77303, United States of America., Sargunas P; Chemical and Biomolecular Engineering and Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218 United States of America., Sharma S; Sachi Bioworks, Louisville, CO 80027, United States of America., Spangler J; Chemical and Biomolecular Engineering and Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218 United States of America., Tavakol DN; Columbia University, New York, NY, 10027, United States of America., Thomas D; Stanford University School of Medicine, Stanford, CA 94305, United States of America., Vunjak-Novakovic G; Columbia University, New York, NY, 10027, United States of America., Wang C; Division of Surgical Sciences, Department of Surgery, Duke University, Durham NC, United States of America., Whitcomb L; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States of America., Young DW; Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, United States of America., Donoviel D; Translational Research Institute for Space Health, Houston, TX 77030, United States of America; Center for Space Medicine, Baylor College of Medicine, Houston, TX 77030, United States of America. Electronic address: donoviel@bcm.edu.
Jazyk: angličtina
Zdroj: Life sciences in space research [Life Sci Space Res (Amst)] 2022 Nov; Vol. 35, pp. 105-112. Date of Electronic Publication: 2022 Aug 07.
DOI: 10.1016/j.lssr.2022.08.003
Abstrakt: Future lunar missions and beyond will require new and innovative approaches to radiation countermeasures. The Translational Research Institute for Space Health (TRISH) is focused on identifying and supporting unique approaches to reduce risks to human health and performance on future missions beyond low Earth orbit. This paper will describe three funded and complementary avenues for reducing the risk to humans from radiation exposure experienced in deep space. The first focus is on identifying new therapeutic targets to reduce the damaging effects of radiation by focusing on high throughput genetic screens in accessible, sometimes called lower, organism models. The second focus is to design innovative approaches for countermeasure development with special attention to nucleotide-based methodologies that may constitute a more agile way to design therapeutics. The final focus is to develop new and innovative ways to test radiation countermeasures in a human model system. While animal studies continue to be beneficial in the study of space radiation, they can have imperfect translation to humans. The use of three-dimensional (3D) complex in vitro models is a promising approach to aid the development of new countermeasures and personalized assessments of radiation risks. These three distinct and unique approaches complement traditional space radiation efforts and should provide future space explorers with more options to safeguard their short and long-term health.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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