Resveratrol improves vascular endothelial dysfunction in the unpredictable chronic mild stress model of depression in rats by reducing inflammation.

Autor: Gacar G; Kocaeli University Center for Stem Cell and Gene Therapies Research and Practice, Institute of Health Sciences, Kocaeli, Turkey., Gocmez SS; Kocaeli University Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey., Halbutoğulları ZS; Kocaeli University Center for Stem Cell and Gene Therapies Research and Practice, Institute of Health Sciences, Kocaeli, Turkey; Kocaeli University Faculty of Medicine, Department of Medical Biology, Kocaeli, Turkey., Kılıç KC; Kocaeli University Center for Stem Cell and Gene Therapies Research and Practice, Institute of Health Sciences, Kocaeli, Turkey., Kaya A; Kocaeli University Center for Stem Cell and Gene Therapies Research and Practice, Institute of Health Sciences, Kocaeli, Turkey., Yazir Y; Kocaeli University Center for Stem Cell and Gene Therapies Research and Practice, Institute of Health Sciences, Kocaeli, Turkey; Kocaeli University Faculty of Medicine, Department of Histology and Embryology, Kocaeli, Turkey., Utkan T; Kocaeli University Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey; Kocaeli University Experimental Medical Research and Application Centre, Kocaeli, Turkey. Electronic address: tijenutkan@hotmail.com.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2023 Feb 13; Vol. 438, pp. 114186. Date of Electronic Publication: 2022 Nov 04.
DOI: 10.1016/j.bbr.2022.114186
Abstrakt: Chronic psychological stress may cause depression and it is a risk factor for vascular endothelial dysfunction. Inflammation may contribute to endothelial dysfunction. Resveratrol, which has antiinflammatory and vasculoprotective properties, has been reported its beneficial effects on endothelial dysfunction induced by hypertension, diabetes and, aging. The effects of resveratrol on stress-induced endothelial dysfunction is not investigated yet. This study aimed to investigate the efficacy of resveratrol on vascular function in the unpredictable chronic moderate stress (UCMS) model of rats and to examine the possible mechanisms of resveratrol by assessment of proinflammatory markers. Male rats were assigned to 4 groups (n = 8 for each group): Control, Control+Resveratrol, UCMS, UCMS+Resveratrol. UCMS and UCMS+Resveratrol groups were exposed to the UCMS procedure for 12 weeks. Resveratrol (20 mg/kg/day, i.p., during 12 weeks) was given to the Control+Resveratrol and UCMS+Resveratrol groups.Then depressive-like behaviors were evaluated by forced swimming test. After behavioral tests, systolic blood pressure was recorded. Endothelial function of the thoracic aorta was evaluated by isolated organ bath system. Vascular eNOS expression and inflammatory markers such as TNF-α, IL-1β, IL-6, CRP, ICAM1, MCP in serum and vascular tissue were analyzed to explore the mechanisms of resveratrol. UCMS resulted in depressive-like behavior, endothelial dysfunction and increased inflammatory cytokines in both serum and tissue samples. Resveratrol treatment improved depressive-like behavior, ameliorated vascular dysfunction, and reversed stress-induced inflammation. Our findings suggest that resveratrol exerted antidepressant-like effect and prevented vascular endothelial dysfunction by reducing systemic and peripheral inflammation in UCMS-induced depression in rats. Therefore, resveratrol may be a therapeutic option with a vasculoprotective effect in depression.
Competing Interests: Declaration of Competing Interest The authors declare that there is no conflict of interest associated with this publication.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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