Current trends in analytical strategies for the chromatographic determination of nitrofuran metabolites in food samples. An update since 2012.

Autor: Melekhin AO; Department of Chemistry, Analytical Chemistry Division, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia; Central Scientific Methodological Veterinary Laboratory, Orangereynaya st., 23, Moscow 111622, Russia., Tolmacheva VV; Department of Chemistry, Analytical Chemistry Division, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia., Apyari VV; Department of Chemistry, Analytical Chemistry Division, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia. Electronic address: apyari@mail.ru., Dmitrienko SG; Department of Chemistry, Analytical Chemistry Division, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia.
Jazyk: angličtina
Zdroj: Journal of chromatography. A [J Chromatogr A] 2022 Dec 06; Vol. 1685, pp. 463620. Date of Electronic Publication: 2022 Oct 29.
DOI: 10.1016/j.chroma.2022.463620
Abstrakt: Nitrofurans (NFs) are synthetic broad-spectrum antibacterial and antiparasitic drugs, which recently were extensively used in veterinary practice. In the body of animals, NFs are converted into carcinogenic and mutagenic metabolites that can be accumulated in foods of animal origin having an adverse effect on human health. Therefore, NFs are currently banned in animal husbandry and aquaculture of many countries. However, the data from monitoring the quality of food products indicate that, despite the prohibitions established by the law, they still are used not only in the developing countries but also in the European Union, due to their high antibacterial activity, low cost, and accessibility. Thus, it is of great importance for human health to develop reliable and sensitive analytical methods for monitoring NF metabolites in animal-derived foods. The objective of this review is to summarize the pretreatment strategies and chromatographic methods that have been reported during the last decade for the determination of NF metabolites in food samples, and to outline the future trends with an emphasis on the novel solutions in this area.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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