Induction of pulmonary HLA-G expression by SARS-CoV-2 infection.

Autor: Seliger B; Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Magdeburger Str. 2, 06112, Halle (Saale), Germany. immunologie@uk-halle.de.; Fraunhofer Institute for Cell Therapy and Immunology, 04103, Leipzig, Germany. immunologie@uk-halle.de.; Institute of Translational Immunology, Medical School 'Theodor Fontane', 14770, Brandenburg, Germany. immunologie@uk-halle.de., Jasinski-Bergner S; Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Magdeburger Str. 2, 06112, Halle (Saale), Germany., Massa C; Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Magdeburger Str. 2, 06112, Halle (Saale), Germany., Mueller A; Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Magdeburger Str. 2, 06112, Halle (Saale), Germany., Biehl K; Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Magdeburger Str. 2, 06112, Halle (Saale), Germany., Yang B; Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Magdeburger Str. 2, 06112, Halle (Saale), Germany., Bachmann M; Helmholtz Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany., Jonigk D; Institute of Pathology, Hannover Medical School, 30625, Hannover, Germany.; German Center for Lung Research (DZL), Hannover Medical School (BREATH), 30625, Hannover, Germany., Eichhorn P; Institute of Pathology, Friedrich-Alexander University, 91054, Erlangen, Germany., Hartmann A; Institute of Pathology, Friedrich-Alexander University, 91054, Erlangen, Germany., Wickenhauser C; Institute of Pathology, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany., Bauer M; Institute of Pathology, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany.
Jazyk: angličtina
Zdroj: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Nov 05; Vol. 79 (11), pp. 582. Date of Electronic Publication: 2022 Nov 05.
DOI: 10.1007/s00018-022-04592-9
Abstrakt: The non-classical human leukocyte antigen (HLA)-G exerts immune-suppressive properties modulating both NK and T cell responses. While it is physiologically expressed at the maternal-fetal interface and in immune-privileged organs, HLA-G expression is found in tumors and in virus-infected cells. So far, there exists little information about the role of HLA-G and its interplay with immune cells in biopsies, surgical specimen or autopsy tissues of lung, kidney and/or heart muscle from SARS-CoV-2-infected patients compared to control tissues. Heterogeneous, but higher HLA-G protein expression levels were detected in lung alveolar epithelial cells of SARS-CoV-2-infected patients compared to lung epithelial cells from influenza-infected patients, but not in other organs or lung epithelia from non-viral-infected patients, which was not accompanied by high levels of SARS-CoV-2 nucleocapsid antigen and spike protein, but inversely correlated to the HLA-G-specific miRNA expression. High HLA-G expression levels not only in SARS-CoV-2-, but also in influenza-infected lung tissues were associated with a high frequency of tissue-infiltrating immune cells, but low numbers of CD8 + cells and an altered expression of hyperactivation and exhaustion markers in the lung epithelia combined with changes in the spatial distribution of macrophages and T cells. Thus, our data provide evidence for an involvement of HLA-G and HLA-G-specific miRNAs in immune escape and as suitable therapeutic targets for the treatment of SARS-CoV-2 infections.
(© 2022. The Author(s).)
Databáze: MEDLINE
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