Adenocarcinoma of the uterine cervix, gastric-type (GAS): a review of the literature focused on pathology and multimodality imaging.

Autor: Kerwin CM; Department of Surgery, University of California San Francisco-East Bay, Oakland, CA, USA. clara.kerwin@ucsf.edu., Markese M; Department of Radiology, University of Colorado School of Medicine, Aurora, CO, USA., Moroney MR; Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA., Smith LP; Department of Pathology, University of Colorado School of Medicine, Aurora, CO, USA., Patel NU; Department of Radiology, University of Colorado School of Medicine, Aurora, CO, USA.
Jazyk: angličtina
Zdroj: Abdominal radiology (New York) [Abdom Radiol (NY)] 2023 Feb; Vol. 48 (2), pp. 713-723. Date of Electronic Publication: 2022 Nov 05.
DOI: 10.1007/s00261-022-03724-w
Abstrakt: Adenocarcinoma of the uterine cervix, gastric-type (GAS) is a rare, well-differentiated subtype of HPV-independent endocervical adenocarcinoma. It classically arises in middle-aged women with symptoms, including profuse watery vaginal discharge and abnormal uterine bleeding. Given the rarity of this disease, misdiagnosis is common and prognosis remains poorly defined. Distinct pathology and imaging findings can aid in diagnosis. A literature review was performed to ascertain recurring pathologic and radiologic characteristics of GAS. Key pathologic features of GAS include cytologically benign appearing mucinous glands that infiltrate into the deep stroma and may demonstrate lymphovascular or perineural invasion. Multiple imaging modalities including transvaginal ultrasound, CT, and MRI may aid in diagnosis of GAS, which characteristically is seen as a multicystic mass with solid components. MRI in particular is the preferred imaging study because it offers the best chance of identifying a potential solid component, which is key to making the diagnosis of GAS and distinguishing it from other endocervical diseases processes. Careful attention to histopathologic and radiologic details, in conjunction with clinical correlation, is necessary to distinguish GAS from other multicystic cervical lesions.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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