Occupational risk variation of nasopharyngeal cancer in the Nordic countries.

Autor: Carpén T; Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, FI-00029 HUS, Helsinki, Finland. timo.carpen@fimnet.fi.; Department of Pathology, University of Helsinki and Helsinki University Hospital, FI-00014, Helsinki, Finland. timo.carpen@fimnet.fi.; Research Program in Systems Oncology, Faculty of Medicine, FI-00014 University of Helsinki, Helsinki, Finland. timo.carpen@fimnet.fi., Gille E; Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, SE-17176, Stockholm, Sweden., Hammarstedt-Nordenvall L; Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, SE-17176, Stockholm, Sweden., Hansen J; Danish Cancer Society Research Center, DK-2100, Copenhagen, Denmark., Heikkinen S; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, FI-00130, Helsinki, Finland., Lynge E; Nykøbing Falster Hospital, University of Copenhagen, DK-4800, Nykøbing Falster, Denmark., Selander J; Institute of Environmental Medicine - IMM Karolinska Institutet, S-17177, Stockholm, Sweden., Mehlum IS; National Institute of Occupational Health (STAMI), N- 0363, Oslo, Norway.; Institute of Health and Society, University of Oslo, N-0450, Oslo, Norway., Torfadottir JE; Icelandic Cancer Registry, IS-105, Reykjavik, Iceland.; Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, IS-102, Reykjavik, Iceland., Mäkitie A; Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, FI-00029 HUS, Helsinki, Finland. antti.makitie@helsinki.fi.; Research Program in Systems Oncology, Faculty of Medicine, FI-00014 University of Helsinki, Helsinki, Finland. antti.makitie@helsinki.fi.; Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, SE-17176, Stockholm, Sweden. antti.makitie@helsinki.fi., Pukkala E; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, FI-00130, Helsinki, Finland.; Health Sciences Unit, Faculty of Social Sciences, FI-33014 Tampere University, Tampere, Finland.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2022 Nov 04; Vol. 22 (1), pp. 1130. Date of Electronic Publication: 2022 Nov 04.
DOI: 10.1186/s12885-022-10209-y
Abstrakt: Background: The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study.
Methods: This study is based on a cohort of almost 15 million persons from Denmark, Finland, Iceland, Norway and Sweden, with 2898 nasopharyngeal cancer cases diagnosed in 1961-2005. The data on occupations were gathered from population censuses and cancer data from the national cancer registries. Standardized incidence ratios (SIR) with 95% confidence intervals (CI) were estimated using the national NPC incidence rates as the reference.
Results: There were 1980 male and 918 female NPC patients. The highest SIRs of NPC were observed among male waiters (SIR 3.69, 95% CI 1.91-6.45) and cooks and stewards (SIR 2.24, 95% CI 1.16-3.91). Among women, launderers had the highest SIR of NPC (2.04, 95% CI 1.02-3.65). Significantly decreased SIRs were found among male farmers (SIR 0.79, 95% CI 0.68-0.92) and male textile workers (SIR 0.49, 95% CI 0.22-0.93).
Conclusions: This study suggests that NPC may be associated with several work-related exposure agents such as smoking, kitchen air pollution and solvents. In future, occupational exposure-risk relations should be studied to understand more about causality and to assess effective prevention strategies.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje