Maternal stress and vulnerability to depression: coping and maternal care strategies and its consequences on adolescent offspring.

Autor: Alves RL; Addiction Biology, i3S - Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal., Portugal CC; Glial Cell Biology, i3S - Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal., Lopes IM; Addiction Biology, i3S - Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal., Oliveira P; Estudos de Populações, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal., Alves CJ; Neuro & Skeletal Circuits, i3S - Instituto de Investigação e Inovação em Saúde and Instituto Nacional de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal., Barbosa F; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal., Summavielle T; Addiction Biology, i3S - Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.; Departamento de Ciências Funcionais, Escola Superior de Saúde (ESS), Politécnico do Porto, Porto, Portugal., Magalhães A; Addiction Biology, i3S - Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal. anam@ibmc.up.pt.; Behavioural Sciences, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal. anam@ibmc.up.pt.; Instituto Universitário de Ciências da Saúde, CESPU, CRL, 4585-116, Gandra, Portugal. anam@ibmc.up.pt.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2022 Nov 04; Vol. 12 (1), pp. 463. Date of Electronic Publication: 2022 Nov 04.
DOI: 10.1038/s41398-022-02220-5
Abstrakt: Depressive mothers often find mother-child interaction to be challenging. Maternal stress may further impair mother-child attachment, which may increase the risk of negative developmental consequences. We used rats with different vulnerability to depressive-like behavior (Wistar and Kyoto) to investigate the impact of stress (maternal separation-MS) on maternal behavior and adolescent offspring cognition. MS in Kyoto dams increased pup-contact, resulting in higher oxytocin levels and lower anxiety-like behavior after weaning, while worsening their adolescent offspring cognitive behavior. Whereas MS in Wistar dams elicited higher quality of pup-directed behavior, increasing brain-derived neurotrophic factor (BDNF) in the offspring, which seems to have prevented a negative impact on cognition. Hypothalamic oxytocin seems to affect the salience of the social environment cues (negatively for Kyoto) leading to different coping strategies. Our findings highlight the importance of contextual and individual factors in the understanding of the oxytocin role in modulating maternal behavior and stress regulatory processes.
(© 2022. The Author(s).)
Databáze: MEDLINE
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