Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure.

Autor: Horiuchi YU; Division of Cardiovascular Medicine, University of California San Diego, La Jolla, CA, USA; Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan., Wettersten N; Division of Cardiovascular Medicine, University of California San Diego, La Jolla, CA, USA; Division of Cardiovascular Medicine, San Diego Veterans Affairs Medical Center, San Diego, CA., VAN Veldhuisen DJ; Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., Mueller C; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland., Filippatos G; Department of Cardiology, Athens University Hospital Attikon, University of Athens, Athens, Greece., Nowak R; Department of Emergency Medicine, Henry Ford Hospital System, Detroit, MI, USA., Hogan C; Division of Emergency Medicine and Acute Care Surgical Services, VCU Medical Center, Virginia Commonwealth University, Richmond, VA, USA., Kontos MC; Division of Cardiology, VCU Medical Center, Virginia Commonwealth University, Richmond, VA, USA., Cannon CM; Department of Emergency Medicine, University of Kansas Medical Center, Kansas City, KS, USA., Müeller GA; Department of Nephrology and Rheumatology, University Medical Centre Göttingen, University of Göttingen, Göttingen, Germany., Birkhahn R; Department of Emergency Medicine, New York Methodist Hospital, New York, NY, USA., Taub P; Division of Cardiovascular Medicine, University of California San Diego, La Jolla, CA, USA., Vilke GM; Department of Emergency Medicine, University of California San Diego, La Jolla, CA, USA., McDonald K; Department of Cardiology, School of Medicine, University College Dublin, Dublin, Ireland; Department of Cardiology, St Vincent's University Hospital, Dublin, Ireland., Mahon N; Department of Cardiology, School of Medicine, University College Dublin, Dublin, Ireland; Department of Cardiology, Mater Misericordiae University Hospital, Dublin, Ireland., Nuñez J; Department of Cardiology, Hospital Clínico Universitario, INCLIVA, Valencia, Spain; Centro de Investigación Biomédica en Red (CIBER) in Cardiovascular Diseases, Madrid, Spain., Briguori C; Department of Cardiology, Mediterranea Cardiocentro, Naples, Italy., Passino C; Department of Cardiology and Cardiovascular Medicine, Fondazione Gabriele Monasterio, Pisa, Italy., Duff S; Department of Medicine, School of Medicine, University College Dublin, Dublin, Ireland., Maisel A; Division of Cardiovascular Medicine, University of California San Diego, La Jolla, CA, USA., Murray PT; Department of Medicine, School of Medicine, University College Dublin, Dublin, Ireland. Electronic address: patrick.murray@ucd.ie.
Jazyk: angličtina
Zdroj: Journal of cardiac failure [J Card Fail] 2023 Mar; Vol. 29 (3), pp. 269-277. Date of Electronic Publication: 2022 Nov 01.
DOI: 10.1016/j.cardfail.2022.09.017
Abstrakt: Background: Galectin-3, a biomarker of inflammation and fibrosis, can be associated with renal and myocardial damage and dysfunction in patients with acute heart failure (AHF).
Methods and Results: We retrospectively analyzed 790 patients with AHF who were enrolled in the AKINESIS study. During hospitalization, patients with galectin-3 elevation (> 25.9 ng/mL) on admission more commonly had acute kidney injury (assessed by KDIGO criteria), renal tubular damage (peak urine neutrophil gelatinase-associated lipocalin [uNGAL] > 150 ng/dL) and myocardial injury (≥ 20% increase in the peak high-sensitivity cardiac troponin I [hs-cTnI] values compared to admission). They less commonly had ≥ 30% reduction in B-type natriuretic peptide from admission to last measured value. In multivariable linear regression analysis, galectin-3 was negatively associated with estimated glomerular filtration rate and positively associated with uNGAL and hs-cTnI. Higher galectin-3 was associated with renal replacement therapy, inotrope use and mortality during hospitalization. In univariable Cox regression analysis, higher galectin-3 was associated with increased risk for the composite of death or rehospitalization due to HF and death alone at 1 year. After multivariable adjustment, higher galectin-3 levels were associated only with death.
Conclusions: In patients with AHF, higher galectin-3 values were associated with renal dysfunction, renal tubular damage and myocardial injury, and they predicted worse outcomes.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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