Molecular typing of dengue virus in Mizoram, Northeast India.

Autor: Sailo CV; Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India., Ghatak S; Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India., Sarathbabu S; Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India., Bariha GS; Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India., Majumder A; Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India., Singh A; Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India., Lalremruata R; Department of Microbiology, Synod Hospital, Durtlang, Aizawl, Mizoram, India., Zomawia E; Hospital and Medical Education, Department of Health and Family Welfare, Government of Mizoram, Aizawl, India., Lalrinpuia B; Department of Physiology, Zoram Medical College, Falkawn, Mizoram, India., Lalfak Zuali; Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India., Zothanzama J; Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India., Senthil Kumar N; Department of Biotechnology, Mizoram University, Aizawl, Mizoram, India. nskmzu@gmail.com.
Jazyk: angličtina
Zdroj: Journal of infection in developing countries [J Infect Dev Ctries] 2022 Oct 31; Vol. 16 (10), pp. 1637-1642. Date of Electronic Publication: 2022 Oct 31.
DOI: 10.3855/jidc.16137
Abstrakt: Introduction: Dengue is an emerging vector-borne public health threat and characterization at the molecular level is important for proper management of the disease. The aim of the study is to examine the diversity of the dengue viral serotypes from a hilly mountainous region of Northeast India.
Methodology: Thirty-six blood samples that were positive for dengue virus IgM antibodies identified by the enzyme-linked immunosorbent assay (ELISA) method were collected and quantified for the IL6 gene expression by using reverse transcriptase polymerase chain reaction (RT-PCR).
Results: All the patients had dengue hemorrhagic fever (DHF); 12 samples had a monotypic infection and 14 samples had dual infection with various dengue virus (DENV) serotypes; one sample had triple infection with DENV-1, DENV-2, and DENV-3.
Conclusions: This study identified DENV-1 as the major serotype in the state of Mizoram and it is the first report on the molecular typing of the dengue virus from the hilly mountainous state located in the Indo-Burma region bordering Myanmar and Bangladesh.
Competing Interests: No Conflict of Interest is declared
(Copyright (c) 2022 Christine Vanlalbiakdiki Sailo, Souvik Ghatak, Subbarayan Sarathbabu, Girija Shankar Bariha, Ayan Majumder, Abhinav Singh, Ralte Lalremruata, Eric Zomawia, Benjamin Lalrinpuia, Lalfak zuali, John Zothanzama, Nachimuthu Senthil Kumar.)
Databáze: MEDLINE
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