| Autor: |
Ferrer MJ; Department of Chemistry, University of Florida, Gainesville, Florida32611-7200, United States., Kuker EL; Department of Chemistry, University of California, Irvine, California92697-2025, United States., Semenova E; Department of Chemistry, University of Florida, Gainesville, Florida32611-7200, United States., Gangano AJ; Department of Chemistry, University of Florida, Gainesville, Florida32611-7200, United States., Lapak MP; Department of Chemistry, University of Florida, Gainesville, Florida32611-7200, United States., Grenning AJ; Department of Chemistry, University of Florida, Gainesville, Florida32611-7200, United States., Dong VM; Department of Chemistry, University of California, Irvine, California92697-2025, United States., Bowers CR; Department of Chemistry, University of Florida, Gainesville, Florida32611-7200, United States.; National High Magnetic Field Lab, Tallahassee, Florida32310, United States. |
| Abstrakt: |
Level anticrossings (LACs) are ubiquitous in quantum systems and have been exploited for spin-order transfer in hyperpolarized nuclear magnetic resonance spectroscopy. This paper examines the manifestations of adiabatic passage through a specific type of LAC found in homonuclear systems of chemically inequivalent coupled protons incorporating parahydrogen (pH 2 ). Adiabatic passage through such a LAC is shown to elicit translation of the pH 2 spin order. As an example, with prospective applications in biomedicine, proton spin polarizations of at least 19.8 ± 2.6% on the methylene protons and 68.7 ± 0.5% on the vinylic protons of selectively deuterated allyl pyruvate ester are demonstrated experimentally. After ultrasonic spray injection of a precursor solution containing propargyl pyruvate and a dissolved Rh catalyst into a chamber pressurized with 99% para-enriched H 2 , the products are collected and transported to a high magnetic field for NMR detection. The LAC-mediated hyperpolarization of the methylene protons is significant because of the stronger spin coupling to the pyruvate carbonyl 13 C, setting up an ideal initial condition for subsequent coherence transfer by selective INEPT. Furthermore, the selective deuteration of the propargyl side arm increases the efficiency and polarization level. LAC-mediated translation of parahydrogen spin order completes the first step toward a new and highly efficient route for the 13 C NMR signal enhancement of pyruvate via side-arm hydrogenation with parahydrogen. |
