Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats.

Autor: Chiariello R; Department of Neurosurgery, Medical College of Wisconsin, United States; Clement J. Zablocki Veterans Affairs Medical Center, United States., McCarthy C; Department of Neurosurgery, Medical College of Wisconsin, United States; Clement J. Zablocki Veterans Affairs Medical Center, United States., Glaeser BL; Department of Pharmacology and Toxicology, Medical College of Wisconsin, United States; Neuroscience Research Center, Medical College of Wisconsin, United States., Shah AS; Department of Neurosurgery, Medical College of Wisconsin, United States; Clement J. Zablocki Veterans Affairs Medical Center, United States., Budde MD; Department of Neurosurgery, Medical College of Wisconsin, United States; Clement J. Zablocki Veterans Affairs Medical Center, United States; Neuroscience Research Center, Medical College of Wisconsin, United States., Stemper BD; Clement J. Zablocki Veterans Affairs Medical Center, United States; Neuroscience Research Center, Medical College of Wisconsin, United States; Joint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, United States., Olsen CM; Department of Neurosurgery, Medical College of Wisconsin, United States; Department of Pharmacology and Toxicology, Medical College of Wisconsin, United States; Neuroscience Research Center, Medical College of Wisconsin, United States. Electronic address: colsen@mcw.edu.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2023 Feb 13; Vol. 438, pp. 114181. Date of Electronic Publication: 2022 Oct 27.
DOI: 10.1016/j.bbr.2022.114181
Abstrakt: Numerous epidemiological studies have found co-morbidity between non-severe traumatic brain injury (TBI) and substance misuse in both civilian and military populations. Preclinical studies have also identified this relationship for some misused substances. We have previously demonstrated that repeated blast traumatic brain injury (rbTBI) increased oxycodone seeking without increasing oxycodone self-administration, suggesting that the neurological sequelae of traumatic brain injury can elevate opioid misuse liability. Here, we determined the chronicity of this effect by testing different durations of time between injury and oxycodone self-administration and durations of abstinence. We found that the subchronic (four weeks), but not the acute (three days) or chronic (four months) duration between injury and oxycodone self-administration was associated with increased drug seeking and re-acquisition of self-administration following a 10-day abstinence. Examination of other abstinence durations (two days, four weeks, or four months) revealed no effect of rbTBI on drug seeking at any of the abstinence durations tested. Together, these data indicate that there is a window of vulnerability after TBI when oxycodone self-administration is associated with elevated drug seeking and relapse-related behaviors.
Competing Interests: Conflict of interest The authors declare no competing financial interests.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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