Correlation of female age with outcome of IVF in a low-resource setting.

Autor: Adebayo FO; Invitro Fertilization Unit, Nisa Fertility and Genetic Center, Abuja, Nigeria., Ameh N; Invitro Fertilization Unit, Nisa Fertility and Genetic Center, Abuja, Nigeria., Adesiyun AG; Department of Obstetrics and Gynecology, Ahmadu Bello University, Zaria, Nigeria., Ekele BA; Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Abuja, Nigeria., Wada I; Invitro Fertilization Unit, Nisa Fertility and Genetic Center, Abuja, Nigeria.
Jazyk: angličtina
Zdroj: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2023 Apr; Vol. 161 (1), pp. 283-288. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.1002/ijgo.14545
Abstrakt: Objective: To determine the effect of female age on pregnancy outcome after in vitro fertilization/embryo transfer (IVF-ET).
Methods: A prospective study was conducted involving 266 women who had IVF-ET at Nisa Fertility and Genetic Center, Abuja, Nigeria. All eligible consenting women were recruited to the study. The main outcome measure was clinical pregnancy. Data were analyzed using IBM SPSS Statistics version 25. P < 0.05 at 95% confidence intervals was taken as significant.
Results: A total of 266 patients were recruited and included in the study; 104 pregnancies were recorded, giving an overall pregnancy rate of 39.1%. The age range of the patient was 26-43 years (mean age 33.9 ± 2.41 years) while the mean number of embryo transfers per patient was 2.2. The clinical pregnancy rate for women aged below 30 years was 69.4% while the pregnancy rate for patients aged 30-34 years, 35-39 years, and 40-43 years was 52.6%, 24.7%, and 9.4%, respectively (P < 0.0001).
Conclusion: The study found that the success rate of IVF-ET decreases significantly in women aged over 34 years. Women should be counseled about the age-related risk of infertility and referred to a fertility center as early as possible.
(© 2022 International Federation of Gynecology and Obstetrics.)
Databáze: MEDLINE
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