Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo.

Autor: Nsiangani Lusambo N; The Department of Eye, University Clinic, Medical School, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Kaimbo Wa Kaimbo D; The Department of Eye, University Clinic, Medical School, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Mumba Ngoyi D; The Department of Parasitology, University Clinic, Medical School, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Kilangalanga Ngoy J; Service of Ophthalmology, Saint Joseph Hospital, Kinshasa, Democratic Republic of Congo., Ngoyi Bambi MT; Service of Ophthalmology, Saint Joseph Hospital, Kinshasa, Democratic Republic of Congo., Kadima Mutombo T; National Eye Care Program, Masina Ophthalmology Hospital, Kinshasa, Democratic Republic of Congo., Kintoki Makela G; National Eye Care Program, Masina Ophthalmology Hospital, Kinshasa, Democratic Republic of Congo., Ngandowe Nzamokili L; National Eye Care Program, Masina Ophthalmology Hospital, Kinshasa, Democratic Republic of Congo., de-la-Torre A; Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT). Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2023 Sep; Vol. 31 (7), pp. 1522-1527. Date of Electronic Publication: 2022 Nov 03.
DOI: 10.1080/09273948.2022.2140297
Abstrakt: Purpose: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).
Method: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.
Results: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01).
Conclusion: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.
Databáze: MEDLINE
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