Engineered upconversion nanocarriers for synergistic breast cancer imaging and therapy: Current state of art.

Autor: Chintamaneni PK; Department of Pharmaceutics, GITAM School of Pharmacy, GITAM (Deemed to be University), Rudraram, 502329 Telangana, India. Electronic address: pchintam@gitam.edu., Nagasen D; Aditya Pharmacy College, Surampalem 533437, India; Jawaharlal Nehru Technological University Kakinada, Kakinada 533003, Andhra Pradesh, India. Electronic address: nagasenpharma@gmail.com., Babu KC; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, Telangana, India., Mourya A; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, Telangana, India., Madan J; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, Telangana, India., Srinivasarao DA; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, Telangana, India. Electronic address: nivasniper@gmail.com., Ramachandra RK; Crystal Growth and Nanoscience Research Center, Department of Physics, Government College (A), Rajamahendravaram, Andhra Pradesh, India; Government Degree College, Chodavaram, Andhra Pradesh, India. Electronic address: drkrcr@gmail.com., Santhoshi PM; Crystal Growth and Nanoscience Research Center, Department of Physics, Government College (A), Rajamahendravaram, Andhra Pradesh, India., Pindiprolu SKSS; Aditya Pharmacy College, Surampalem 533437, India; Jawaharlal Nehru Technological University Kakinada, Kakinada 533003, Andhra Pradesh, India. Electronic address: saikiran.pss@adityapharmacy.edu.in.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2022 Dec; Vol. 352, pp. 652-672. Date of Electronic Publication: 2022 Nov 08.
DOI: 10.1016/j.jconrel.2022.10.056
Abstrakt: Breast cancer is the most common type of cancer in women and is the second leading cause of cancer-related deaths worldwide. Early diagnosis and effective therapeutic interventions are critical determinants that can improve survival and quality of life in breast cancer patients. Nanotheranostics are emerging interventions that offer the dual benefit of in vivo diagnosis and therapeutics through a single nano-sized carrier. Rare earth metal-doped upconversion nanoparticles (UCNPs) with their ability to convert near-infrared light to visible light or UV light in vivo settings have gained special attraction due to their unique luminescence and tumor-targeting properties. In this review, we have discussed applications of UCNPs in drug and gene delivery, photothermal therapy (PTT), photodynamic therapy (PDT) and tumor targeting in breast cancer. Further, present challenges and future opportunities for UCNPs in breast cancer treatment have also been mentioned.
Competing Interests: Declaration of Competing Interest None to declare.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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