Infection of SARS-CoV-2 in domestic dogs associated with owner viral load.

Autor: de Souza Barbosa AB; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81531-970, Brazil., Kmetiuk LB; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81531-970, Brazil., de Carvalho OV; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81531-970, Brazil; TECSA Laboratories, Belo Horizonte, MG 30110-042, Brazil., Brandão APD; Department of Preventive Medicine, School of Medicine, University of São Paulo (USP), São Paulo, SP 01246-903, Brazil., Doline FR; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81531-970, Brazil., Lopes SRRS; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81531-970, Brazil., Meira DA; Departments of Genetic and of Cellular Biology and of Biochemistry and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81530-000, Brazil., de Souza EM; Departments of Genetic and of Cellular Biology and of Biochemistry and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81530-000, Brazil., da Silva Trindade E; Departments of Genetic and of Cellular Biology and of Biochemistry and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81530-000, Brazil., Baura V; Departments of Genetic and of Cellular Biology and of Biochemistry and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81530-000, Brazil., Barbosa DS; Graduate College of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG 31270-901, Brazil., Brandespim DF; Department of Veterinary Medicine, College of Veterinary Medicine, Federal Rural University of Pernambuco (UFRPE), Recife, PE 52171-900, Brazil., Galhardo JA; Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS 79070-900, Brazil., Pettan-Brewer C; Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA., de Sá Guimarães AM; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP 05508-000, Brazil., Dutra V; Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Mato Grosso (UFMT), Cuiabá, MT 78060-900, Brazil., de Morais HA; Department of Clinical Sciences, Oregon State University, Corvallis, OR 97331, USA., Huergo L; Federal University of Paraná (UFPR), Seashore Campus, Matinhos, PR 83260-000, Brazil., Dos Santos AP; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA., Biondo AW; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, PR 81531-970, Brazil; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA. Electronic address: abiondo@ufpr.br.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2022 Dec 31; Vol. 153, pp. 61-65. Date of Electronic Publication: 2022 Oct 13.
DOI: 10.1016/j.rvsc.2022.10.006
Abstrakt: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive pet owners are reported to be a risk factor for infection of their pets; however, the influence of the viral load and associated risks has not been fully established. This study aimed to assess potential association of viral load in owners with the presence of SARS-CoV-2 infection in their dogs. Of 20 SARS-CoV-2-positive pet owners from 13 families in Curitiba, Brazil, 5 of 22 (22.7%) dogs were positive for SARS-CoV-2. Viral presence was detected in oropharyngeal samples for 2 of 5 (40.0%) dogs at 8 and 9 days after the first positive sample. Detection of SARS-CoV-2 in these dogs was associated with higher viral loads in the owners and close owner contact. All 5 RT-qPCR-positive dogs had antibodies to at least one viral protein tested in the serological assay. Molecular detection of SARS-CoV-2 in dogs was statistically associated with clinical signs in owners such as cold, cough, or diarrhea (P = 0.039), number of positive persons in the household (P = 0.002), and higher viral load (P = 0.039). Such findings serve as a warning for risks of human to dog infection, mainly due to sharing beds and other close interactions without protection. In conclusion, people with coronavirus disease 2019 (COVID-19), particularly in households with multiple residents and high viral load, should take the same preventive measures when interacting with their dogs during self-isolation as they do with people.
Competing Interests: Declaration of Competing Interest The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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