Subjective and objective cognitive function in adolescent with chronic fatigue following Epstein-Barr virus infection.

Autor: Øie MG; Department of Psychology, University of Oslo, P.O. Box 1094, 0317 Oslo, Norway. Electronic address: m.g.oie@psykologi.uio.no., Rødø ASB; Department of Psychology, University of Oslo, P.O. Box 1094, 0317 Oslo, Norway., Bølgen MS; Department of Psychology, University of Oslo, P.O. Box 1094, 0317 Oslo, Norway., Pedersen M; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Dept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway., Asprusten TT; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Dept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway., Wyller VBB; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Dept. of Pediatrics and Adolescent Health, Akershus University Hospital, Lørenskog, Norway.
Jazyk: angličtina
Zdroj: Journal of psychosomatic research [J Psychosom Res] 2022 Dec; Vol. 163, pp. 111063. Date of Electronic Publication: 2022 Oct 17.
DOI: 10.1016/j.jpsychores.2022.111063
Abstrakt: Objective: Cognitive difficulties are among the most disruptive and disabling problems reported by chronic fatigue syndrome (CFS) sufferers. Acute Epstein-Barr virus (EBV) infection is a trigger of chronic fatigue (CF) and CFS. The aim of this study was to investigate subjectively reported and objectively measured cognitive functioning in fatigued and non-fatigued adolescents six months after EBV infection.
Methods: A total of 195 adolescents (12-19 years) with acute EBV infection were followed prospectively for six months, after which they were grouped as chronically fatigued (CF + ) and non-fatigued (CF - ) cases based on questionnaire score; the CF + -group was further subgrouped according to CFS diagnosis. A group of 70 healthy controls was also included. Groups were cross-sectionally compared on objective measures of processing speed, executive functions and memory, and subjective cognitive functioning.
Results: There were no group differences regarding objective cognitive measures, but the CF + -group reported significantly (p < 0.001) more cognitive problems (cognitive symptoms sum score = 9.5) compared to the CF - -group (cognitive symptoms sum score = 5.3) and the healthy control group (cognitive symptoms sum score = 6.4). The CFS subgroup rated symptoms scores even higher but did not differ on cognitive performance tests.
Conclusion: Subjective experiences of cognitive difficulties characterize adolescents with CF and CFS six months after acute EBV infection, whereas objective measures of cognitive impairment are inconspicuous.
Competing Interests: Declaration of Competing Interest None of the authors have conflict of interest or financial relationships relevant to this article to disclose.
(Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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