The impact of mild cognitive impairment on decision-making under explicit risk conditions: Evidence from the Personality and Total Health (PATH) Through Life longitudinal study.

Autor:	Sinclair C; School of Psychology, University of New South Wales, Sydney, Australia.; Australian Research Council Centre of Excellence in Population Ageing Research, University of New South Wales, Sydney, Australia.; UNSW Ageing Futures Institute, University of New South Wales, Sydney, Australia.; Neuroscience Research Australia (NeuRA), Sydney, Australia., Eramudugolla R; School of Psychology, University of New South Wales, Sydney, Australia.; UNSW Ageing Futures Institute, University of New South Wales, Sydney, Australia., Cherbuin N; Australian Research Council Centre of Excellence in Population Ageing Research, University of New South Wales, Sydney, Australia.; Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia., Mortby ME; School of Psychology, University of New South Wales, Sydney, Australia.; UNSW Ageing Futures Institute, University of New South Wales, Sydney, Australia.; Neuroscience Research Australia (NeuRA), Sydney, Australia., Anstey KJ; School of Psychology, University of New South Wales, Sydney, Australia.; UNSW Ageing Futures Institute, University of New South Wales, Sydney, Australia.; Neuroscience Research Australia (NeuRA), Sydney, Australia.; Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2023 Jul; Vol. 29 (6), pp. 594-604. Date of Electronic Publication: 2022 Nov 03.
DOI:	10.1017/S1355617722000765
Abstrakt:	Objective: Previous research has indicated that cognition and executive function are associated with decision-making, however the impact of mild cognitive impairment (MCI) on decision-making under explicit risk conditions is unclear. This cross-sectional study examined the impact of MCI, and MCI subtypes, on decision-making on the Game of Dice Task (GDT), among a cohort of older adults. Method: Data from 245 older adult participants (aged 72-78 years) from the fourth assessment of the Personality and Total Health Through Life study were analyzed. A diagnostic algorithm identified 103 participants with MCI, with subtypes of single-domain amnestic MCI (aMCI-single; n = 38), multi-domain amnestic MCI (aMCI-multi; n = 31), and non-amnestic MCI ( n = 33), who were compared with an age-, sex-, education-, and income-matched sample of 142 cognitively unimpaired older adults. Decision-making scores on the GDT (net score, single number choices, and strategy changes) were compared between groups using nonparametric tests. Results: Participants with MCI showed impaired performance on the GDT, with higher frequencies of single number choices and strategy changes. Analyses comparing MCI subtypes indicated that the aMCI-multi subtype showed increased frequency of single number choices compared to cognitively unimpaired participants. Across the sample of participants, decision-making scores were associated with measures of executive function (cognitive flexibility and set shifting). Conclusion: MCI is associated with impaired decision-making performance under explicit risk conditions. Participants with impairments in multiple domains of cognition showed the clearest impairments. The GDT may have utility in discriminating between MCI subtypes.
Databáze:	MEDLINE
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