Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study.
| Autor: | Rennerova Z; Department of Paediatric Pulmonology and Phthisiology, Faculty of Medicine, Slovak Medical University, National Children Institute of Health, Bratislava, Slovakia., Picó Sirvent L; Paediatrics Department, Hospital de la Salud, Valencia, Spain.; Faculty of Medicine and Health Sciences, Valencia Catholic University Saint Vincent Martyr, Valencia, Spain., Carvajal Roca E; Paediatrics Department, Hospital de la Salud, Valencia, Spain.; Faculty of Medicine and Health Sciences, Valencia Catholic University Saint Vincent Martyr, Valencia, Spain., Paśnik J; Salve Medica Warszawa, Warsaw, Poland., Logar M; Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.; Department of Infectious Diseases and Epidemiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Milošević K; Department of Pulmonology and Allergology, University Children's Hospital, Belgrade, Serbia.; School of Medicine, University of Belgrade, Belgrade, Serbia., Majtan J; Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia.; Department of Microbiology, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia., Jesenak M; Department of Paediatrics, Jessenius Faculty of Medicine, University Teaching Hospital in Martin, Comenius University in Bratislava, Martin, Slovakia.; Department of Clinical Immunology and Allergology, University Teaching Hospital in Martin, Martin, Slovakia. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in pediatrics [Front Pediatr] 2022 Oct 14; Vol. 10, pp. 999701. Date of Electronic Publication: 2022 Oct 14 (Print Publication: 2022). |
| DOI: | 10.3389/fped.2022.999701 |
| Abstrakt: | Preschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors. Preventing and/or treating children suffering from recurrent respiratory tract infections (RRTIs) is challenging, and it is important to provide more clinical evidence about the safety and efficacy of natural immunomodulating preparations, including β-glucans. The aim of the present study was to assess the incidence of respiratory tract infections (RTIs) in children with a history of RRTIs for a period of 6 months (3 months of pleuran supplementation and 3 months of follow-up) compared with the same period from October to March of the previous year prior to enrolment in the study. A total of 1,030 children with a mean age of 3.49 ± 1.91 years from seven countries were included in this study. The total number of RTIs observed during the study period was significantly lower compared to the same period of the previous year (7.07 ± 2.89 vs. 3.87 ± 3.19; p < 0.001). Analysis of each type of RTI revealed significant reductions in the mean number and duration of infections for all RTI subtypes compared to the previous year. This study also confirmed the beneficial safety profile of pleuran supplementation. In conclusion, pleuran supplementation represents an interesting and prospective supplement in preventing respiratory infections and reveals new strategies for supporting immune functions in the paediatric population. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2022 Rennerova, Picó Sirvent, Carvajal Roca, Paśnik, Logar, Milošević, Majtan and Jesenak.) |
| Databáze: | MEDLINE |
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