Acute Generalized Exanthematous Pustulosis in a Setting of Cutaneous Lymphoma.
| Autor: | Budh DP; Internal Medicine, St. Barnabas Hospital Health System, Bronx, USA., Hawa S; Epidemiology and Population Health, Stanford University School of Medicine, Stanford, USA., Rios D; Internal Medicine, St. Barnabas Hospital Health System, Bronx, USA., Chilakala A; Internal Medicine, St. Barnabas Hospital Health System, Bronx, USA., Paniagua JA; Internal Medicine, St. Barnabas Hospital Health System, Bronx, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Sep 29; Vol. 14 (9), pp. e29754. Date of Electronic Publication: 2022 Sep 29 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.29754 |
| Abstrakt: | Acute generalized exanthematous pustulosis (AGEP) is a rare dermatological manifestation of the adverse drug reaction that occurs for a varied duration after the receipt of certain drugs. It manifests as an acute onset of generalized exanthematous pustular reaction with an edematous base. It has a characteristic clinical presentation and rapid resolution soon after the removal of the offending drug. The unique histological finding is that of single-cell necrosis of keratinocytes with edema of papillary dermis accompanied by components of vasculitis and/or exocytosis of eosinophils. Management consists of moist antiseptic dressings, topical steroids, infliximab, the use of systemic steroids if needed, and avoiding antibiotics as much as possible. Here, we present a case of AGEP in a setting of usages of antibiotics like vancomycin, cefepime, and ceftriaxone in a patient with cutaneous lymphoma that resolved after withdrawal of the offending antibiotics. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Budh et al.) |
| Databáze: | MEDLINE |
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