Wireless neuromodulation in vitro and in vivo by intrinsic TRPC-mediated magnetomechanical stimulation.

Autor: Su CL; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan, R.O.C., Cheng CC; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan, R.O.C., Yen PH; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan, R.O.C., Huang JX; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan, R.O.C., Ting YJ; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan, R.O.C., Chiang PH; Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan, R.O.C.. phc@nycu.edu.tw.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2022 Nov 02; Vol. 5 (1), pp. 1166. Date of Electronic Publication: 2022 Nov 02.
DOI: 10.1038/s42003-022-04124-y
Abstrakt: Various magnetic deep brain stimulation (DBS) methods have been developing rapidly in the last decade for minimizing the invasiveness of DBS. However, current magnetic DBS methods, such as magnetothermal and magnetomechanical stimulation, require overexpressing exogeneous ion channels in the central nervous system (CNS). It is unclear whether magnetomechanical stimulation can modulate non-transgenic CNS neurons or not. Here, we reveal that the torque of magnetic nanodiscs with weak and slow alternative magnetic field (50 mT at 10 Hz) could activate neurons through the intrinsic transient receptor potential canonical channels (TRPC), which are mechanosensitive ion channels widely expressed in the brain. The immunostaining with c-fos shows the increasement of neuronal activity by wireless DBS with magnetomechanical approach in vivo. Overall, this research demonstrates a magnetic nanodiscs-based magnetomechanical approach that can be used for wireless neuronal stimulation in vitro and untethered DBS in vivo without implants or genetic manipulation.
(© 2022. The Author(s).)
Databáze: MEDLINE
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