Combined plasma levels of IL-10 and testosterone, but not soluble HLA-G5, predict the risk of death in COVID-19 patients.

Autor: Amodio G; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele, Milan, Italy., Capogrosso P; Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.; Department of Urology and Andrology, Ospedale di Circolo and Macchi Foundation, Varese, Italy., Pontillo M; Laboratory Medicine Service, IRCCS Ospedale San Raffaele, Milan, Italy., Tassara M; Laboratory Medicine Service, IRCCS Ospedale San Raffaele, Milan, Italy., Boeri L; Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.; IRCCS Foundation Ca' Granda, Maggiore Policlinico Hospital, Department of Urology, University of Milan, Milan, Italy., Carenzi C; Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy., Cignoli D; Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy., Ferrara AM; Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy., Ramirez GA; University Vita-Salute San Raffaele, Milan, Italy.; Immunology, Rheumatology, Allergology and Rare Diseases Unit, IRCCS Ospedale San Raffaele, Milan, Italy., Tresoldi C; Molecular Hematology Unit, IRCCS Ospedale San Raffaele, Milan, Italy., Locatelli M; Laboratory Medicine Service, IRCCS Ospedale San Raffaele, Milan, Italy., Santoleri L; Immunohematology and Transfusion Medicine, IRRCS Ospedale San Raffaele, Milan, Italy., Castagna A; University Vita-Salute San Raffaele, Milan, Italy.; Department of Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Zangrillo A; University Vita-Salute San Raffaele, Milan, Italy.; Anesthesia and Intensive Care Department, IRCCS Ospedale San Raffaele, Milan, Italy., De Cobelli F; University Vita-Salute San Raffaele, Milan, Italy.; Department of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy., Tresoldi M; General Medicine and Advanced Care Unit, IRCCS Ospedale San Raffaele, Milan, Italy., Landoni G; University Vita-Salute San Raffaele, Milan, Italy.; Anesthesia and Intensive Care Department, IRCCS Ospedale San Raffaele, Milan, Italy., Rovere-Querini P; University Vita-Salute San Raffaele, Milan, Italy.; Internal Medicine, Diabetes, and Endocrinology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ciceri F; University Vita-Salute San Raffaele, Milan, Italy.; Hematology and Bone Marrow Transplant Unit, IRCCS Ospedale San Raffaele, Milan, Italy., Montorsi F; Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy., Salonia A; Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.; University Vita-Salute San Raffaele, Milan, Italy., Gregori S; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele, Milan, Italy.
Jazyk: angličtina
Zdroj: Andrology [Andrology] 2023 Jan; Vol. 11 (1), pp. 32-44. Date of Electronic Publication: 2022 Nov 21.
DOI: 10.1111/andr.13334
Abstrakt: Background: The identification of biomarkers correlated with coronavirus disease 2019 (COVID-19) outcomes is a relevant need for clinical management. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by elevated interleukin (IL)-6, IL-10, HLA-G, and impaired testosterone production.
Objectives: We aimed at defining the combined impact of sex hormones, interleukin-10, and HLA-G on COVID-19 pathophysiology and their relationship in male patients.
Materials and Methods: We measured by chemiluminescence immunoassay, electrochemiluminescent assays, and enzyme-linked immunosorbent assay circulating total testosterone, 17β-estradiol (E 2 ), IL-10, and -HLAG5 as well as SARS-CoV-2 S1/S2 Immunoglobulin G from 292 healthy controls and 111 COVID-19 patients with different disease severity at hospital admission, and in 53 COVID-19 patients at 7-month follow-up.
Results and Discussion: We found significantly higher levels of IL-10, HLA-G, and E 2 in COVID-19 patients compared to healthy controls and an inverse correlation between IL-10 and testosterone, with IL-10, progressively increasing and testosterone progressively decreasing with disease severity. This correlation was lost at the 7-month follow-up. The risk of death in COVID-19 patients with low testosterone increased in the presence of high IL-10. A negative correlation between SARS-CoV-2 Immunoglobulin G and HLA-G or IL-10 at hospitalization was observed. At the 7-month follow-up, IL-10 and testosterone normalized, and  HLA-G decreased.
Conclusion: Our findings indicate that combined evaluation of IL-10 and testosterone predicts the risk of death in men with COVID-19 and support the hypothesis that IL-10 fails to suppress excessive inflammation by promoting viral spreading.
(© 2022 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology.)
Databáze: MEDLINE
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