Flavones interact with fiber to affect fecal bacterial communities in vitro.

Autor: Loo YT; School of Agriculture & Food, Faculty of Veterinary & Agricultural Sciences, The University of Melbourne, Victoria 3010, Australia., Howell K; School of Agriculture & Food, Faculty of Veterinary & Agricultural Sciences, The University of Melbourne, Victoria 3010, Australia., Suleria H; School of Agriculture & Food, Faculty of Veterinary & Agricultural Sciences, The University of Melbourne, Victoria 3010, Australia., Zhang P; School of Agriculture & Food, Faculty of Veterinary & Agricultural Sciences, The University of Melbourne, Victoria 3010, Australia., Liu S; School of Agriculture & Food, Faculty of Veterinary & Agricultural Sciences, The University of Melbourne, Victoria 3010, Australia., Ng K; School of Agriculture & Food, Faculty of Veterinary & Agricultural Sciences, The University of Melbourne, Victoria 3010, Australia. Electronic address: ngkf@unimelb.edu.au.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2023 Mar 15; Vol. 404 (Pt B), pp. 134721. Date of Electronic Publication: 2022 Oct 26.
DOI: 10.1016/j.foodchem.2022.134721
Abstrakt: This study investigated the effects of the sugarcane flavones diosmin, diosmetin, luteolin, and tricin, and their interactions with sugarcane fiber on the modulation of gut microbiota using in vitro batch fermentation. The alteration of fecal fermentation bacterial profile was analyzed using 16S rRNA sequencing data, while the bioavailability of fiber was indicated by short-chain fatty acid (SCFA) production and metabolism of polyphenols was measured directly by phenolic metabolites. Application of diosmin, diosmetin, luteolin, and tricin without fiber had no significant effect on the overall microbiota profile after 24 h of fermentation. When fiber alone was added, total SCFA production increased, specifically that of propionic and valeric acids. However, when flavones were combined with fiber, synergistic effects on the modulation of relative abundances of different bacterial taxa was noted. In particular, the proportion of Prevotella spp. was significantly increased by the combinations of diosmin, luteolin, and tricin with fiber.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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