A Review of the Abscopal Effect in the Era of Immunotherapy.
| Autor: | Nabrinsky E; Hematology and Oncology, Advocate Lutheran General Hospital, Park Ridge, USA., Macklis J; Hematology and Oncology, Advocate Lutheran General Hospital, Park Ridge, USA., Bitran J; Hematology and Oncology, Advocate Lutheran General Hospital, Park Ridge, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Sep 26; Vol. 14 (9), pp. e29620. Date of Electronic Publication: 2022 Sep 26 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.29620 |
| Abstrakt: | The abscopal effect is a systemic immune response mediated by the effects of radiation on the immune system. This effect has been observed in a number of cancer types in addition to lung cancer, including but not limited to renal cell carcinoma, hepatocellular carcinoma, lymphoma, and melanoma. The combination of radiation therapy and immune checkpoint inhibition (ICI) acts at several stages of the antitumor response, suggesting a mechanism of synergy between the two modalities. This review focuses on recent advances in the understanding of the effect of radiation and immunotherapy in the context of the abscopal effect. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Nabrinsky et al.) |
| Databáze: | MEDLINE |
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