Influence of SERPINA1 Gene Polymorphisms on Anemia and Chronic Obstructive Pulmonary Disease.

Autor:	Sangeetha T; Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India., Nargis Begum T; Department of Biotechnology, Jamal Mohammed College, Tiruchirapalli, Tamil Nadu, India., Balamuralikrishnan B; Department of Food Science and Biotechnology, Sejong University, Seoul, Republic of Korea., Arun M; Department of Life Sciences, Christ Deemed to be University, Bengaluru, India., Rengasamy KRR; Laboratory of Natural Products and Medicinal Chemistry (LNPMC), Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu 600077, India.; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa., Senthilkumar N; Chemistry and Bioprospecting Division, Institute of Forest Genetics and Tree Breeding (IFGTB-ICFRE), Coimbatore, Tamil Nadu, India., Velayuthaprabhu S; Department of Biotechnology, Bharathiar University, Tamil Nadu, India., Saradhadevi M; Department of Biochemistry, Bharathiar University, Tamil Nadu, India., Sampathkumar P; Department of Chemistry and Biosciences, SASTRA Deemed to be University, Kumbakonam, Tamil Nadu, India., Vijaya Anand A; Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India.
Jazyk:	angličtina
Zdroj:	Journal of the renin-angiotensin-aldosterone system : JRAAS [J Renin Angiotensin Aldosterone Syst] 2022 Oct 17; Vol. 2022, pp. 2238320. Date of Electronic Publication: 2022 Oct 17 (Print Publication: 2022).
DOI:	10.1155/2022/2238320
Abstrakt:	Background: Anemia is one of the predominant hematological conditions, whereas chronic obstructive pulmonary disease (COPD) is a predominant respiratory disease. These two diseases were found to be interlinked, but the physiological pathways are still unclear. Aim: The current study has been aimed at analysing the genetic interrelationship between anemia and COPD in accordance with different altitudes. Methodology . The genetic analysis was performed in the SERPINA1 gene of anemia, COPD, and healthy individuals for the analysis of single nucleotide polymorphism at rs28949274 and rs17580 locations. Result and Discussion . The single nucleotide polymorphism at the locations rs28949274 and rs17580 was present in both anemic and COPD patients. The COPD patients were more prone to mutations (63% had rs28949274, and 11% had rs17580 polymorphisms) than the anemic patients (40% had rs28949274, and 1% had rs17580 polymorphisms). On the basis of altitude, high-altitude individuals were found to be more susceptible to both the polymorphisms. Conclusion: Based on the current findings, we suggest that the SERPINA1 gene has a positive correlation with anemia as well as COPD, and the increase in altitude also influences the diseased conditions in a positive manner. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2022 Thangavelu Sangeetha et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu