Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer.

Autor: Han QF; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.; Henan Research Centre for Organ Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China., Li WJ; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research Center, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, 510120, China., Hu KS; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research Center, Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou, 510120, China., Gao J; Henan Research Centre for Organ Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.; Henan Diagnosis & Treatment League for Hepatopathy, Zhengzhou, 450052, Henan, China., Zhai WL; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. fcczhaiwl@zzu.edu.cn., Yang JH; Clinical Systems Biology Key Laboratories of Henan, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. jyang@bu.edu., Zhang SJ; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. zhangshuijun@zzu.edu.cn.; Henan Research Centre for Organ Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. zhangshuijun@zzu.edu.cn.; Henan Diagnosis & Treatment League for Hepatopathy, Zhengzhou, 450052, Henan, China. zhangshuijun@zzu.edu.cn.; Henan Engineering & Research Center for Diagnosis and Treatment of Hepatobiliary and Pancreatic Surgical Diseases, Zhengzhou, 450052, Henan, China. zhangshuijun@zzu.edu.cn.
Jazyk: angličtina
Zdroj: Molecular cancer [Mol Cancer] 2022 Nov 01; Vol. 21 (1), pp. 207. Date of Electronic Publication: 2022 Nov 01.
DOI: 10.1186/s12943-022-01671-0
Abstrakt: Exosomes are well-known key mediators of intercellular communication and contribute to various physiological and pathological processes. Their biogenesis involves four key steps, including cargo sorting, MVB formation and maturation, transport of MVBs, and MVB fusion with the plasma membrane. Each process is modulated through the competition or coordination of multiple mechanisms, whereby diverse repertoires of molecular cargos are sorted into distinct subpopulations of exosomes, resulting in the high heterogeneity of exosomes. Intriguingly, cancer cells exploit various strategies, such as aberrant gene expression, posttranslational modifications, and altered signaling pathways, to regulate the biogenesis, composition, and eventually functions of exosomes to promote cancer progression. Therefore, exosome biogenesis-targeted therapy is being actively explored. In this review, we systematically summarize recent progress in understanding the machinery of exosome biogenesis and how it is regulated in the context of cancer. In particular, we highlight pharmacological targeting of exosome biogenesis as a promising cancer therapeutic strategy.
(© 2022. The Author(s).)
Databáze: MEDLINE
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