Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia.

Autor: Bernard-Raichon L; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA., Venzon M; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA., Klein J; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Axelrad JE; Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Zhang C; Institute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA., Sullivan AP; Institute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA., Hussey GA; Institute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA., Casanovas-Massana A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Noval MG; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., Valero-Jimenez AM; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., Gago J; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA.; Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA., Putzel G; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Pironti A; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Wilder E; Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Thorpe LE; Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Littman DR; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Dittmann M; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., Stapleford KA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., Shopsin B; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, New York University Grossman School of Medicine, New York, NY, USA., Torres VJ; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Ko AI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Iwasaki A; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Cadwell K; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA. ken.cadwell@nyulangone.org.; Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. ken.cadwell@nyulangone.org.; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA. ken.cadwell@nyulangone.org.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA. ken.cadwell@nyulangone.org., Schluter J; Institute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA. jonas.schluter@nyulangone.org.; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA. jonas.schluter@nyulangone.org.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA. jonas.schluter@nyulangone.org.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Nov 01; Vol. 13 (1), pp. 5926. Date of Electronic Publication: 2022 Nov 01.
DOI: 10.1038/s41467-022-33395-6
Abstrakt: Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces gut microbiome dysbiosis in mice, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, including blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19.
(© 2022. The Author(s).)
Databáze: MEDLINE
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