Analgesic and Sedative-Hypnotic Potentiality of Crude Methanolic Extract of Gomphandra tetrandra (Wall.) Sleumer Leaves.
| Autor: | Bhuiya NMMA; Jagannath University, Department of Pharmacy, Dhaka, Bangladesh., Hossen F; Jagannath University, Department of Pharmacy, Dhaka, Bangladesh., Islam M; Northern University Bangladesh, Department of Pharmacy, Dhaka, Bangladesh., Hasan M; Jagannath University, Department of Pharmacy, Dhaka, Bangladesh. |
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| Jazyk: | angličtina |
| Zdroj: | Turkish journal of pharmaceutical sciences [Turk J Pharm Sci] 2022 Oct 31; Vol. 19 (5), pp. 583-588. |
| DOI: | 10.4274/tjps.galenos.2021.09216 |
| Abstrakt: | Objectives: Gomphandra tetrandra (Wall.) Sleumer (leaves) belonging to the family Stemonuraceae was investigated for preliminary phytochemical screening and evaluating their pharmacological activities in various pharmacological models. Materials and Methods: The crude methanolic extract was screened with different chemical reagents for the qualitative detection of different phytochemical groups. The peripheral analgesic function was determined using the acetic acid-induced writhing procedure and sedative-hypnotic behaviors were assessed using hole-board, open field, and hole-cross tests using different doses of the extract (200 mg/kg and 400 mg/kg body weight). Results: Phytochemical screening revealed that methanolic extract of G. tetranda leaves contains steroids, gums, mucilages, phytosterols, carbohydrates, and flavonoids. The crude methanolic extract at 200 mg/kg and 400 mg/kg doses showed statistically significant activity in acetic acid-induced writhing inhibition test with 60% ( p <0.01) and 76.47% ( p <0.01) inhibition, respectively, compared to control. The extract also had dose-dependent substantial ( p <0.01) sedative-hypnotic activities compared with diazepam in the hole-board, open field, and hole-cross tests. Conclusion: It may be assumed that the methanolic leaf extract of G. tetrandra possesses a strong possibility of having analgesic and sedative-hypnotic activity due to the presence of bioactive compounds in its leaves. Moreover, observed results have opened a new era of in-depth research to discover the possible mechanism of analgesic and sedative-hypnotic activity. Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors. (©Turk J Pharm Sci, Published by Galenos Publishing House.) |
| Databáze: | MEDLINE |
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