Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination.

Autor: Fourati S; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA., Tomalin LE; Center for Biostatistics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mulè MP; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID and Center for Human Immunology (CHI), NIH, Bethesda, MD, USA.; NIH-Oxford-Cambridge Scholars Program, Cambridge University, Cambridge, UK., Chawla DG; Yale School of Medicine, New Haven, CT, USA., Gerritsen B; Yale School of Medicine, New Haven, CT, USA., Rychkov D; Division of Transplant Surgery, University of California, San Francisco, San Francisco, CA, USA., Henrich E; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Miller HER; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hagan T; Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Diray-Arce J; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Dunn P; ImmPort Curation Team, NG Health Solutions, Rockville, MD, USA., Levy O; Precision Vaccines Program, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Gottardo R; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Biomedical Data Science Center, University of Lausanne and Lausanne University Hospital, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Sarwal MM; Division of Transplant Surgery, University of California, San Francisco, San Francisco, CA, USA., Tsang JS; Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID and Center for Human Immunology (CHI), NIH, Bethesda, MD, USA., Suárez-Fariñas M; Center for Biostatistics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Pulendran B; Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Kleinstein SH; Yale School of Medicine, New Haven, CT, USA. steven.kleinstein@yale.edu., Sékaly RP; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA. rafick.sekaly@emory.edu.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2022 Dec; Vol. 23 (12), pp. 1777-1787. Date of Electronic Publication: 2022 Oct 31.
DOI: 10.1038/s41590-022-01329-5
Abstrakt: Several studies have shown that the pre-vaccination immune state is associated with the antibody response to vaccination. However, the generalizability and mechanisms that underlie this association remain poorly defined. Here, we sought to identify a common pre-vaccination signature and mechanisms that could predict the immune response across 13 different vaccines. Analysis of blood transcriptional profiles across studies revealed three distinct pre-vaccination endotypes, characterized by the differential expression of genes associated with a pro-inflammatory response, cell proliferation, and metabolism alterations. Importantly, individuals whose pre-vaccination endotype was enriched in pro-inflammatory response genes known to be downstream of nuclear factor-kappa B showed significantly higher serum antibody responses 1 month after vaccination. This pro-inflammatory pre-vaccination endotype showed gene expression characteristic of the innate activation state triggered by Toll-like receptor ligands or adjuvants. These results demonstrate that wide variations in the transcriptional state of the immune system in humans can be a key determinant of responsiveness to vaccination.
(© 2022. The Author(s).)
Databáze: MEDLINE
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