Ligand- and Substrate-Controlled para C-H Borylation of Anilines at Room Temperature.

Autor: Haldar C; Department of Biological & Synthetic Chemistry, Center of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.; Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India., Bisht R; Department of Biological & Synthetic Chemistry, Center of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India., Chaturvedi J; Department of Biological & Synthetic Chemistry, Center of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India., Guria S; Department of Biological & Synthetic Chemistry, Center of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India., Hassan MMM; Department of Biological & Synthetic Chemistry, Center of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India., Ram B; Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India., Chattopadhyay B; Department of Biological & Synthetic Chemistry, Center of Biomedical Research, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.
Jazyk: angličtina
Zdroj: Organic letters [Org Lett] 2022 Nov 11; Vol. 24 (44), pp. 8147-8152. Date of Electronic Publication: 2022 Oct 31.
DOI: 10.1021/acs.orglett.2c03188
Abstrakt: A new catalytic method for para borylation of unprotected anilines is described. The catalytic method is developed by designing a new type of ligand framework that enables para borylation at room temperature. We showed that whereas previously reported para borylation of 2-substituted anilines required multistep protection/deprotection sequences and a high reaction temperature, our method gives a straightforward solution for achieving para borylation without such protection/deprotection chemistry at room temperature.
Databáze: MEDLINE
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