Clostridioides difficile infection recurrence in the VINCat hospitals: a prospective observational cohort study.

Autor:	Pujol M; VINCat Nosocomial Infection Surveillance in Catalonia, Barcelona, 08028, Spain.; Department of Infectious Diseases, Bellvitge University Hospital, L'Hospitalet de Llobregat; Institut d'Investigació Biomèdica de Bellvitge (IDBELL), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Limón E; VINCat Nosocomial Infection Surveillance in Catalonia, Barcelona, 08028, Spain.; Department of Public Health, Mental Health & Mother-Infant Nursing, School of Nursing, Faculty of Medicine & Health Sciences, University of Barcelona, Spain., Sopena N; Infectious Diseases Service, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain., Lopez-Contreras J; Infectious Diseases Unit - Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Institut de Recerca del Hospital de la Santa Creu i Sant Pau, University Autónoma de Barcelona, Barcelona, Spain., Castellá L; Department of Nursing, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain., Cuquet J; Department of Internal Medicine, Hospital General de Granollers, Barcelona, Spain., López-Sánchez M; Infectious Diseases Unit, Hospital Universitari Mútua Terrassa, Barcelona, Spain., Pérez R; Department of Internal Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Gudiol C; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.; Department of Infectious Diseases, Bellvitge University Hospital, Institut Català d'Oncologia-Hospitalet, Barcelona; Institut d'Investigació Biomèdica de Bellvitge (IDBELL), Barcelona, Spain., Coloma A; Department of Internal Medicine, H Moisès Broggi, Sant Joan Despi, Barcelona, Spain., Marimón M; Department of Health-related Infection Control, Hospital Universitari General de Catalunya Quiron Salud, Barcelona, Spain., Espinach J; Department Internal Medicine, Fundació Hospital Sant Joan de Déu de Martorell, Barcelona, Spain., Andres M; Infectious Diseases Unit, Internal Medicine Service, Hospital de Terrassa (Consorci Sanitari de Terrassa), Terrassa, Spain., Martos P; Department of Infectious Diseases, Bellvitge University Hospital, L'Hospitalet de Llobregat; Institut d'Investigació Biomèdica de Bellvitge (IDBELL), Barcelona, Spain., Hernández S; VINCat Nosocomial Infection Surveillance in Catalonia, Barcelona, 08028, Spain., Almendral A; VINCat Nosocomial Infection Surveillance in Catalonia, Barcelona, 08028, Spain., Saliba P; VINCat Nosocomial Infection Surveillance in Catalonia, Barcelona, 08028, Spain., Rodrigues GC; VINCat Nosocomial Infection Surveillance in Catalonia, Barcelona, 08028, Spain., Calbo E; VINCat Nosocomial Infection Surveillance in Catalonia, Barcelona, 08028, Spain.; Infectious Diseases Unit, Hospital Universitari Mútua Terrassa, Barcelona, Spain.; Universitat Internacional de Catalunya, Barcelona, Spain., Group VP; VINCat Nosocomial Infection Surveillance in Catalonia, Barcelona, 08028, Spain.
Jazyk:	angličtina
Zdroj:	Future microbiology [Future Microbiol] 2022 Dec; Vol. 17, pp. 1445-1453. Date of Electronic Publication: 2022 Oct 31.
DOI:	10.2217/fmb-2022-0076
Abstrakt:	Background: The 2016 cumulative incidence of Clostridioides difficile infection (CDI) in Spain was reported by the European Center for Disease Control to be above the mean of other European countries. The aim of this multicenter prospective observational cohort study was to examine the risk factors that determine 90-day CDI recurrence in Catalonia, Spain. Methods: The study included 558 consecutive adults admitted to hospital who had a symptomatic, first positive CDI diagnosis. Sociodemographic, clinical and epidemiological variables were recorded. The primary outcome was 90-day CDI recurrence. Results: In this Catalan population, having received more than one course of antibiotics in the 30 days prior to CDI diagnosis (odds ratio: 2.459; 95% CI: 1.195-5.060; p = 0.015) and active chemotherapy (odds ratio: 4.859; 95% CI: 1.495-15.792; p = 0.009) are significant predictors of 90-day CDI recurrence. Conclusion: The identification of independent risk factors of 90-day CDI recurrence will enable the optimization of preventive measures in at-risk populations.
Databáze:	MEDLINE
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